Results 91 to 100 of about 15,989 (217)

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

Comparing outcomes after pulmonary vein isolation in patients with systolic and diastolic heart failure

Heart Rhythm O2
Background: The benefit of pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF) is well established; its efficacy in patients with heart failure preserved ejection fraction ...
Ahmad B. Allaw, MD, Jeremy Treger, MD, PhD, Jia Guo, MD, Dipayon Roy, MD, Amulya Gampa, MD, Swati Rao, MD, Stephanie A. Besser, MSAS, Andrew D. Beaser, MD, Zaid Aziz, MD, Cevher Ozcan, MD, Srinath Yeshwant, MD, Gaurav A. Upadhyay, MD   +11 more
doaj   +1 more source

Exploring the early observations of parents supporting their children with school attendance problems (SAPs): A co‐produced study

British Educational Research Journal, EarlyView.
Abstract School Attendance Problems (SAPs) represent a significant challenge requiring early identification and intervention. Current service provision often does not recognise early indicators that parents observe, creating gaps between when initial concerns are raised and formal support is provided.
Tereza Aidonopoulou‐Read, Michelle Pyer, Beth Bodycote, Jackie Campbell, Kirsteen Pyer   +4 more
wiley   +1 more source

Association between endothelial activation and stress index and 30-day mortality risk in acute myocardial infarction patients: a study based on the medical information mart for intensive care-IV database

BMC Cardiovascular Disorders
Objective This study aimed to evaluate the association between the Endothelial Activation and Stress Index (EASIX) and 30-day mortality risk in acute myocardial infarction (AMI) patients.
Mingmin Sang, Xiaofeng Ma, Fangyi Zhu, Cunkui Zhu, Zuohua Ying   +4 more
doaj   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Cardiac Arrhythmias [PDF]

BMJ, 1954
openaire   +2 more sources

A Novel Potential Pathway Linking Cardiac Diseases and Cognitive Dysfunction: Impaired Brain Glymphatic Function

Brain Health, EarlyView.
ABSTRACT Growing evidence confirms that cardiac diseases and cognitive dysfunction are closely related. Multiple cardiac diseases have been identified as important risk factors for cognitive impairment and dementia. Notably, recent studies suggest that cardiac diseases are associated not only with vascular cognitive impairment but also with an ...
Jiahuan Guo, Yuliang Qin, Xingquan Zhao
wiley   +1 more source

Novel brain SPECT imaging unravels abnormal cerebral perfusion in patients with postural orthostatic tachycardia syndrome and cognitive dysfunction

Scientific Reports
Cognitive dysfunction is frequently reported in individuals with postural orthostatic tachycardia syndrome (POTS), possibly resulting from reduced cerebral blood flow (CBF).
Marie-Claire Seeley, Howard O’Brien, Gemma Wilson, Clair Coat, Tess Smith, Kevin Hickson, Reynold Casse, Amanda J. Page, Celine Gallagher, Dennis H. Lau   +9 more
doaj   +1 more source

Clinical Anatomy of the Left and Right Atrial Appendages in Humans: Comparative and Developmental Perspective

Clinical Anatomy, EarlyView.
ABSTRACT Human atrial chambers derive from distinct embryonic anlagens, the original embryonic atria gradually transforming into the so‐called auricles, or atrial appendages. This study quantifies macroscopic variations in pectinate muscle architecture in human atrial appendages and evaluates their visualization using clinical imaging modalities.
Markéta Lexová, Caroline Neradilová, Jan Kovanda, Jan Burkert, Jiří Beneš Jr., Martin Bartos, Theodor Adla, Vojtech Melenovsky, Alena Kvasilova, Ondrej Fabian, Ondrej Naňka, David Sedmera   +11 more
wiley   +1 more source

Quo Vadis in Anatomical Research? Preserving the Conditions for Discovery in an Era of Predictable Outcomes

Clinical Anatomy, EarlyView.
ABSTRACT Contemporary anatomical research has become increasingly integrated with clinical practice, generating substantial benefits for patient care and strengthening the translational relevance of the discipline. At the same time, some of the most influential anatomical advances have emerged from investigations whose eventual significance could not ...
Joe Iwanaga, Shane Tubbs
wiley   +1 more source