Results 111 to 120 of about 543,312 (350)
Circulation, 2019 Left ventricular assist devices (LVADs) are an increasingly used strategy for the management of patients with advanced heart failure with reduced ejection fraction.
Rakesh Gopinathannair +9 more
semanticscholar +1 more source
TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2
Advanced Science, EarlyView.This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao +12 more
wiley +1 more source
Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases
Advanced Science, EarlyView.Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh +17 more
wiley +1 more source
, 2006 Andersen-Tawil syndrome (ATS) is a rare condition consisting of ventricular arrhythmias, periodic paralysis, and dysmorphic features. In 2001, mutations in KCNJ2, which encodes the α subunit of the potassium channel Kir2.1, were identified in patients ...
Fish, Frank A +2 more
core +2 more sources
Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System
Advanced Electronic Materials, EarlyView.This work combines a conductive collagen‐based hydrogel with a laser‐cut and assembly technique to fabricate microphysiological systems that improve extracellular recordings of cardiomyocytes in 3D on microelectrode arrays. The inclusion of choline acrylate into GelMA imparts a higher electrical conductivity and improves the signal‐to‐noise ratio of on‐
Dominic Pizzarella +4 more
wiley +1 more source
BJS (British Journal of Surgery), EarlyView., 2020 All patients operated for oesophageal cancer in Sweden from 2013 to April 2018 were identified, and 246 patients were recruited to this population‐based nationwide Swedish study. The results show that longitudinal health‐related quality of life after minimally invasive oesophagectomy was similar to that of the open surgical approach.
F. Klevebro +4 more
wiley +1 more source
AI‐Assisted Bioelectronics for Personalized Health Management
Advanced Electronic Materials, EarlyView.Recent advances in artificial intelligence (AI)‐assisted bioelectronics, including materials, device fabrication, working mechanisms, AI‐hardware integration, and proof‐of‐concept applications in digital health management, are summarized. The emergence of AI‐assisted bioelectronic systems and potential solutions to existing challenges are discussed ...
Huiwen Xiong +6 more
wiley +1 more source
Identification of cavotricuspid isthmus voltage patterns in typical atrial flutter ablation
Journal of ArrhythmiaBackground Electroanatomical mapping is an essential tool in the ablation of typical AFL. Objectives To identify the existence of voltage patterns in the CTI voltage maps and their relevance for typical AFL ablation.
Francisco Ribes +5 more
doaj +1 more source
Journal of Arrhythmia, 2013 Left ventricular non-compaction (LVNC) cardiomyopathy is a rare congenital disorder, classified by the American Heart Association as a primary genetic cardiomyopathy and characterized by multiple trabeculations within the left ventricle.
Oana Dickinson +6 more
doaj +1 more source
Unexpected impairment of INa underpins reentrant arrhythmias in a knock-in swine model of Timothy syndrome [PDF]
, 2023 Andreu Porta‐Sánchez +24 more
openalex +1 more source