Background Left atrial structural remodeling contributes to the arrhythmogenic substrate of atrial fibrillation (AF), but the role of the right atrium (RA) remains unknown.
Clara Gunturiz‐Beltrán +16 more
doaj +1 more source
Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme. [PDF]
In this issue of EMBO Molecular Medicine, Decher et al (2017) identify a point mutation in the K2P2 (TREK‐1) potassium (K+) channel that changes function in just those ways expected to predispose to right ventricular outflow tract (RVOT) ventricular
Goldstein, Steve An
core +2 more sources
A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y. [PDF]
Thousands die each year from sudden infant death syndrome (SIDS). Neither the cause nor basis for varied prevalence in different populations is understood.
Bowers, Peter N +8 more
core +2 more sources
Cardiac safety of tiotropium in patients with cardiac events: a retrospective analysis of the UPLIFT® trial. [PDF]
BackgroundTiotropium is an anticholinergic bronchodilator for symptom relief and reducing exacerbations with an established safety profile in patients with chronic obstructive pulmonary disease (COPD).
Decramer, Marc +3 more
core +1 more source
Perioperative arrhythmias are common depending on the type of the operation and can increase morbidity and mortality.This review is based on pertinent publications retrieved by a selective search in PubMed, as well as the relevant European guidelines.Arrhythmias are seen in more than 90% of cardiac operations; they are usually transient and often ...
Simon, Pecha +2 more
openaire +2 more sources
Infarct tissue characterization in implantable cardioverter-defibrillator recipients for primary versus secondary prevention following myocardial infarction: a study with contrast-enhancement cardiovascular magnetic resonance imaging [PDF]
Knowledge about potential differences in infarct tissue characteristics between patients with prior life-threatening ventricular arrhythmia versus patients receiving prophylactic implantable cardioverter-defibrillator (ICD) might help to improve the ...
Birgelen, C. von +7 more
core +3 more sources
Arrhythmias are the most commonly encountered cardiovascular complicationsduring anesthesia administration. Perioperative arrhythmias disrupt thehemodynamic state of the patients and are known to cause increases in mortalityand morbidity. Anesthetic agents and methods affect cardiac conduction andcause arrhythmia.
Altınbaş, Ali +2 more
openaire +3 more sources
Angiopoietin-2 predicts morbidity in adults with Fontan physiology. [PDF]
Morbidity in patients with single-ventricle Fontan circulation is common and includes arrhythmias, edema, and pulmonary arteriovenous malformations (PAVM) among others. We sought to identify biomarkers that may predict such complications.
Aboulhosn, Jamil A +8 more
core
Hepatocyte growth factor gene therapy reduces ventricular arrhythmia in animal models of myocardial ischemia. [PDF]
It was recently reported that gene therapy using hepatocyte growth factor (HGF) has the potential to preserve cardiac function after myocardial ischemia. We speculated that this HGF gene therapy could also prevent ventricular arrhythmia.
Aoki, Motokuni +7 more
core +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source

