Results 41 to 50 of about 266,319 (309)

Epilepsy Is a Risk Factor for Sudden Cardiac Arrest in the General Population [PDF]

, 2012
Background People with epilepsy are at increased risk for sudden death. The most prevalent cause of sudden death in the general population is sudden cardiac arrest (SCA) due to ventricular fibrillation (VF). SCA may contribute to the increased incidence
Bardai, A, Berdowski, J, Blom, MT, Brouwer, HJ, Koster, RW, Lamberts, RJ, Sander, JW, Spanjaart, AM, Tan, HL, Thijs, RD, van der Staal, SR   +10 more
core   +1 more source

Meta‐Rod Mechanical Metamaterials With Programmable Reconfiguration

Advanced Functional Materials, EarlyView.
Existing mechanical metamaterials achieve programmable large deformations in planar square or cubic configurations, restricted by required complex boundary conditions. This research proposes a 1D metamaterial, Meta‐rod, with linear, bending, twisting, area, and volume deformation modes.
Atharva Pande, Lyes Kadem, Hang Xu
wiley   +1 more source

Regulation of gap junction function; the role of nitric oxide. [PDF]

, 2013
Myocardial ischemia resulting from sudden occlusion of a coronary artery is one of the major causes in the appearance of severe, often life-threatening ventricular arrhythmias.
Gönczi, Márton, Kovács, Mária, Miskolczi, Gottfried, Végh, Ágnes   +3 more
core   +2 more sources

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

A comparative study of early afterdepolarization-mediated fibrillation in two mathematical models for human ventricular cells [PDF]

, 2015
Early afterdepolarizations (EADs), which are abnormal oscillations of the membrane potential at the plateau phase of an action potential, are implicated in the development of cardiac arrhythmias like Torsade de Pointes.
Nayak, Alok Ranjan, Pandit, Rahul, Panfilov, Alexander, Vandersickel, Nele, Zimik, Soling   +4 more
core   +6 more sources

Frequency of Cardiac Arrhythmias in Hypertensive Patients

Pakistan Armed Forces Medical Journal, 2022
Objective: To determine the frequency of cardiac arrhythmias in hypertensive patients. Study Design: Analytical Cross -sectional study. Place & Duration of Study: Tertiary Cardiac Center, Lahore Pakistan from Jan 2021 to Dec2021. Methodology:
Muhammad Naeem Tariq, Naseer Ahmed Samore, Muhammad Humayoun Rashid, Sohail Aziz, Ghoza Chaudhery, Jahanzab Ali, Naseem Azad, Ahmad Noeman, Syeda Neelam Yamin Bukhari, Azhar Ali Chaudhry   +9 more
doaj   +1 more source

Early afterdepolarisations and ventricular arrhythmias in cardiac tissue: a computational study

, 2009
Afterdepolarisations are associated with arrhythmias in the heart, but are difficult to study experimentally. In this study we used a simplified computational model of 1D and 2D cardiac ventricular tissue, where we could control the size of the region ...
Clayton, R.H., Scarle, S.
core   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Calmodulinopathy: Functional Effects of CALM Mutations and Their Relationship With Clinical Phenotypes

Frontiers in Cardiovascular Medicine, 2018
In spite of the widespread role of calmodulin (CaM) in cellular signaling, CaM mutations lead specifically to cardiac manifestations, characterized by remarkable electrical instability and a high incidence of sudden death at young age.
Beatrice Badone, Carlotta Ronchi, Maria-Christina Kotta, Luca Sala, Alice Ghidoni, Lia Crotti, Lia Crotti, Lia Crotti, Antonio Zaza   +8 more
doaj   +1 more source

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations. [PDF]

, 2019
Drug-induced block of the cardiac rapid delayed rectifying potassium current (I Kr), carried by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of acquired long QT syndrome.
Chen, I-Shan, Furutani, Kazuharu, Handa, Kenichiro, Kurachi, Yoshihisa, Sack, Jon T, Tsumoto, Kunichika, Yamakawa, Yuko   +6 more
core   +1 more source