Results 51 to 60 of about 266,319 (309)

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Diagnostic yield and variant reassessment in the genes encoding Nav1.5 channel in Russian patients with Brugada syndrome

Frontiers in Pharmacology, 2022
Brugada syndrome (BrS) is an inherited cardiac arrhythmia characterized by ST-elevation, negative T-wave, and a high risk of sudden cardiac death (SCD) due to ventricular tachycardia.
Elena Zaklyazminskaya, Elena Zaklyazminskaya, Anna Shestak, Dmitry Podolyak, Vera Komoliatova, Leonid Makarov, Anna Novitskaya, Amiran Revishvili   +7 more
doaj   +1 more source

Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]

, 2016
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia, Brock, Mathew, Chan, Dulciana, Chvatal, Stacie, Crumb, William J., Galeotti, Loriano, Hortigon-Vinagre, Maria P., Johannesen, Lars, Lyn-Cook, Beverly, Millard, Daniel, Pang, Li, Ross, James, Smith, Godfrey, Stockbridge, Norman, Stohlman, Jayna, Strauss, David G., Vicente, Jose, Zamora Rodriguez, Victor   +17 more
core   +1 more source

Soft Ionic and Electronic Triboelectric Nanogenerators: Toward Attachable and Implantable Biomedical Applications

Advanced Materials, EarlyView.
This review provides an overview of triboelectric nanogenerator (TENG)–based biomedical applications by classifying studies into electronic and ionic systems across attachable and implantable platforms. It summarizes key material choices, device structures, and working mechanisms that characterize current TENG‐based research, and outlines six future ...
Kyongtae Choi, Jimin Park, Won Jun Song, Soohwan An, Seonggyu Choe, Byeong‐Rak Keum, Min Young Kim, Dae Hee Hwang, Young‐Geun Park, Sung‐Won Kim, Sangyul Baik, Gwang‐Bum Im, Younghoon Lee   +12 more
wiley   +1 more source

Heart arrhythmias and conduction disorders in patients with acromegaly: the role of cardiac magnetic resonance imaging

Терапевтический архив, 2020
Cardiovascular complications including arrhythmias and cardiac conduction disorders are one of the main reasons of high mortality rate in acromegaly, while they have not been well explored. Aim.To estimate arrhythmias frequency in acromegaly, identify
K. V. Melkozerov, E. G. Przhiyalkovskaya, N. V. Tarbaeva, A. A. Almaskhanova, M. D. Kuklina, P. A. Alferova, I. S. Gomova, L. A. Belousov, Z. E. Belaya, A. V. Vorontsov, V. Y. Kalashnikov   +10 more
doaj   +1 more source

Convolutional neural network for classification of eight types of arrhythmia using 2D time–frequency feature map from standard 12-lead electrocardiogram

Scientific Reports, 2021
Electrocardiograms (ECGs) are widely used for diagnosing cardiac arrhythmia based on the deformation of signal shapes due to changes in various heart diseases.
Da Un Jeong, Ki Moo Lim
doaj   +1 more source

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, EarlyView.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source

Prevalence of arterial hypertension in young elite athletes with a hypertensive type of response to physical activity

Спортивная медицина: наука и практика
Aim of the study: to assess the prevalence of arterial hypertension in athletes with high BP values during an exercise test.Methods: out of 2313 athletes 14–18 (15.5 ± 1.4) years old, according to the results of VEM, 128 (6 %; 60 m) people with high ...
V. N. Komoliatova, D. A. Besportochnii, L. M. Makarov, I. I. Kiseleva, N. V. Aksenova   +4 more
doaj   +1 more source

Proarrhythmia associated with antiarrhythmic drugs: a comprehensive disproportionality analysis of the FDA adverse event reporting system

Frontiers in Pharmacology, 2023
Objective: This study aimed to identify the different associations between antiarrhythmic drugs (AADs) and arrhythmias, and to determine whether pharmacokinetic drug interactions involving AADs increase the risk of AAD-related arrhythmias compared to ...
Feifei Wang, Bingfeng Zhou, Hongwei Sun, Xinan Wu   +3 more
doaj   +1 more source

Tissue Tracking Imaging for Identifying the Origin of Idiopathic Ventricular Arrhythmias: A New Role of Cardiac Ultrasound in Electrophysiology [PDF]

, 2005
Several strategies for mapping ventricular outflow tract tachycardia have been reported as useful indices for differentiating between those originating from the right and the left side.
Roy TN, Sunil, Sankar, Vikram, Francis, Johnson, Tada, Hiroshi   +3 more
core