Results 101 to 110 of about 524,035 (381)

LncDARS‐AS1 Regulates ATP1A1 Stability and Enhances Na+/K+ ATPase Activity to Promote Osteosarcoma Metastasis

Advanced Science, EarlyView.
This study identifies LncDARS‐AS1 as a novel oncogenic regulator that stabilizes ATP1A1 and enhances Na⁺/K⁺ ATPase activity, promoting osteosarcoma metastasis. Targeting the LncDARS‐AS1/ATP1A1/NKA axis, including pharmacological inhibition with digoxin, offers promising opportunities for the development of new therapeutic strategies against ...
Mingxian Xu, Jiatian Wei, Xiaoyu Feng, Qinkai Zhang, Jian Chen, Xinyue Wang, Xiudan Zhan, Bing Lu, Weitang Guo, Mingzhe Cheng, Renxuan Huang, Shao Xu, Changye Zou   +12 more
wiley   +1 more source

Local impedance and contact force guidance to predict successful cavotricuspid isthmus ablation with a zero-fluoroscopy approach

Frontiers in Cardiovascular Medicine
IntroductionA new technology capable of monitoring local impedance (LI) and contact force (CF) has recently been developed. At the same time, there is growing concern regarding catheter ablation performed under fluoroscopy guidance, due to its harmful ...
Jorge Melero-Polo, Mercedes Cabrera-Ramos, Jose Manuel Alfonso-Almazán, Isabel Marín-García, Isabel Montilla-Padilla, José Ramón Ruiz-Arroyo, Guillermo López-Rodríguez, Javier Ramos-Maqueda   +7 more
doaj   +1 more source

Apln-CreERT:mT/mG reporter mice as a tool for sprouting angiogenesis study

BMC Ophthalmology, 2017
Background Angiogenesis is defined as a new blood vessel sprouting from pre-existing vessels, and the sprouting angiogenesis is the start phase of angiogenesis, which is critical for both physiological and pathological processes, such as embryonic ...
Jingjiang Pi, Yu Cheng, Huimin Sun, Xiaoli Chen, Tao Zhuang, Jie Liu, Yixi Li, Huan Chang, Lin Zhang, YuZhen Zhang, Ting Tao   +10 more
doaj   +1 more source

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Advanced Science, EarlyView.
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu   +9 more
wiley   +1 more source

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice

Nature Communications, 2016
Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart disease. One of the most frequent and potentially life threatening disorders of DM-induced heart disease is ventricular tachycardia (VT).
G. Monnerat, M. L. Alarcón, L. R. Vasconcellos, Camila Hochman-Mendez, G. Brasil, R. A. Bassani, Ó. Casis, D. Malan, L. Travassos, Marisa N. Sepúlveda, J. I. Burgos, M. Vila-Petroff, F. F. Dutra, M. Bozza, C. Paiva, A. B. Carvalho, A. Bonomo, B. Fleischmann, A. C. D. de Carvalho, E. Medei   +19 more
semanticscholar   +1 more source

High‐Throughput MicroED for Probing Ion Channel Dynamics

Advanced Science, EarlyView.
High‐throughput MicroED offers a new approach for visualizing ion channel dynamics. This approach reveals NaK’s sodium binding modes and NaK2CNG’s potassium‐induced selectivity filter dilation and gating. By capturing these distinct structures, this work challenges traditional models of ion channel permeation and selectivity. Abstract Ion channels play
Marc J Gallenito, Max TB Clabbers, Jieye Lin, Johan Hattne, Tamir Gonen   +4 more
wiley   +1 more source

Ventricular Arrhythmias in First Acute Myocardial Infarction: Epidemiology, Mechanisms, and Interventions in Large Animal Models

Frontiers in Cardiovascular Medicine, 2019
Ventricular arrhythmia and subsequent sudden cardiac death (SCD) due to acute myocardial infarction (AMI) is one of the most frequent causes of death in humans.
S. Sattler, Lasse Skibsbye, D. Linz, A. Lubberding, J. Tfelt‐Hansen, T. Jespersen   +5 more
semanticscholar   +1 more source

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

Advanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sangyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng, Li Li   +9 more
wiley   +1 more source

Atrial arrhythmias, digitalis and potassium [PDF]

, 1959
K. I. Melville
openalex   +2 more sources

Qualitative transcriptional signatures for evaluating the maturity degree of pluripotent stem cell-derived cardiomyocytes

Stem Cell Research & Therapy, 2019
Background Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) are widely used models for regenerative medicine and disease research. However, PSC-CMs are usually immature in morphology and functionality and the maturity of PSC-CMs could not be ...
Rou Chen, Jun He, Yumei Wang, You Guo, Juan Zhang, Luying Peng, Duo Wang, Qin Lin, Jie Zhang, Zheng Guo, Li Li   +10 more
doaj   +1 more source