Results 121 to 130 of about 264,698 (302)

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

A narrative review of inherited arrhythmogenic syndromes in young population: role of genetic diagnosis in exercise recommendations

BMJ Open Sport & Exercise Medicine
Sudden cardiac death is a rare but socially devastating event, especially if occurs in young people. Usually, this unexpected lethal event occurs during or just after exercise. One of the leading causes of sudden cardiac death is inherited arrhythmogenic
Elena Arbelo, Gonzalo Grazioli, Carles Díez-López, Oscar Campuzano, Georgia Sarquella-Brugada, Sergi Cesar, Estefanía Martínez-Barrios, Rocío Toro, José Cruzalegui, Andrea Greco, Nuria Díez-Escuté, Patricia Cerralbo, Fredy Chipa, Norma Balderrábano   +13 more
doaj   +1 more source

Electrocardiographic repolarization parameters in children with arrhythmias and excessive body weight

Introduction In clinical diagnosis, electrocardiographic repolarization abnormalities with prolongation of QT and especially TpTe intervals are important for assessing the risk of malignant ventricular arrhythmias. The aim of the study was to compare the
Agnieszka Chlebowczyk, Szyd\u141owski, Les\u141aw, Joanna Jaromin, Lesław Szydłowski, Moric-Janiszewska, Ewa, Ewa Moric-Janiszewska, Markiewicz-\u141oskot, Gra\u17cyna, Agnieszka Kulawik, Chlebowczyk, Agnieszka, Kulawik, Agnieszka, Grażyna Markiewicz-Łoskot, Jaromin, Joanna   +11 more
core   +1 more source

Advancing Environmental Sustainability: The Role of Artificial Intelligence in Monitoring, Predicting, and Controlling Sulfur Dioxide Emissions

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Air pollution from sulfur dioxide (SO2) emissions poses significant threats to environmental sustainability, public health, and climate change efforts. Despite advances in monitoring and regulatory frameworks, traditional methods often fall short in accuracy, scalability, and efficiency.
Turkan Kopac
wiley   +1 more source

Student engagement in the anatomical sciences: What gets in the way?

Anatomical Sciences Education, EarlyView.
Abstract Active learning has become central to anatomical sciences education, yet its effectiveness largely depends on student engagement. Here we define the anatomical sciences as gross anatomy, surface anatomy, neuroanatomy, embryology, histology, and integrated radiology.
Kasidy K. Dobish, Kathryn B. Moore, Danielle M. Delucchi, Stephen L. Jenkins, Geoffrey T. Dorius, David A. Morton   +5 more
wiley   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

The Role of Immune Cells Driving Electropathology and Atrial Fibrillation

Cells
Atrial fibrillation (AF) is the most common progressive cardiac arrhythmia worldwide and entails serious complications including stroke and heart failure. Despite decades of clinical research, the current treatment of AF is suboptimal.
Mingxin Huang, Fabries G. Huiskes, Natasja M. S. de Groot, Bianca J. J. M. Brundel   +3 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

The Interplay Between Pulmonary Hypertension and Atrial Fibrillation: A Comprehensive Overview

Cells
Pulmonary hypertension (PH) is a progressive lung disease characterized by abnormal pulmonary vascular pressure and right ventricular (RV) dysfunction. Atrial arrhythmias, including atrial fibrillation (AF) and atrial flutter, are common in patients with
Danish Sultan, Bianca J. J. M. Brundel, Kondababu Kurakula   +2 more
doaj   +1 more source