Results 101 to 110 of about 264,698 (302)

Dynamic Expression of the Type 1 Brugada ECG Pattern During Tilt Table Testing Using Continuous High Precordial Lead Positioning

Diagnostics
Background/Objectives: The Type 1 Brugada ECG pattern (BrP1) fluctuates according to autonomic influences. Tilt table testing induces changes in both sympathetic and parasympathetic activity. It may provide insights into the dynamic behavior of BrP1 when
Eduardo Nolla Silva Pereira, Luciana Sacilotto, Tan Chen Wu, Gabrielle D’Arezzo Pessente, Nemer Luis Pichara, Denise Tessariol Hachul, Mauricio Ibrahim Scanavacca, Francisco Carlos da Costa Darrieux   +7 more
doaj   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Macrophage GLUD1 is Essential for Redox Balance and Immune Homeostasis in Cardiac Injury

Advanced Science, EarlyView.
Excessive free radical production and dysregulated immune responses are key contributors to myocardial ischemia‐reperfusion (IR) injury. Macrophage GLUD1 activity safeguards against HIF‐1α accumulation and maladaptive responses to IR‐induced ROS production.
Tingting Jin, Chaojie Lai, Qingyan Zhou, Ruilin Wang, Yiping Tong, Wentao Chen, Nikola Rabrenovic, Tingyu Zhang, Xinrong Ren, Chengchen Huang, Jiawen Chen, Ran Li, Luyang Yu, Massimiliano Mazzone, Wenbin Zhang, Guosheng Fu, Min Shang   +16 more
wiley   +1 more source

Oral cardioversion with flecainide in supraventricular arrhythmias

, 1993
Flecainide is a class 1C antiarrhythmic drug with proven efficacy by the intravenous route in terminating supraventricular arrhythmias. Pharmacokinetic studies evidenced how its administration as acute oral loading dose obtains therapeutic drug levels ...
Biffi, M., Lenzi, T., Boriani, G., Cavazza, M., Trisolino, G., Magnani, B., Capucci, A., Binetti, N., Spedicato, L.   +8 more
core  

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Cardiac arrhythmias during long-duration spaceflights

, 2014
Few studies have investigated cardiac arrhythmias during spaceflight. Atrial and ventricular premature contractions, short-duration atrial fibrillation, and non-sustained ventricular tachycardia were reported by previous spaceflight programs.
Tagayasu Anzai, MD, Akihiko Nogami, MD, PhD, Mary Anne Frey, PhD   +2 more
core   +2 more sources

Arrhythmias and the Healed Myocardial Infarction

, 1989
The major hypothesis guiding our studies of arrhythmias in experimental healed myocardial infarction is that during the evolution and subsequent healing of experimental myocardial infarction, some tissues exposed to ischemic injury heal, but persisting ...
Castellanos, Agustin, Bassett, Arthur L, Kimura, Shinichi, Kozlovskis, Patricia L, Huikuri, Heikki, Myerburg, Robert J, Agustin Castellanos, Robert J. Myerburg, Shinichi Kimura, Heikki Huikuri, Patricia L. Kozlovskis, Arthur L. Bassett   +11 more
core   +1 more source

Single‐Nucleus RNA Sequencing Identifies CREM as a Brake on Myofiber Hypertrophy in Chickens

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing on 91 144 nuclei from postnatal chicken pectoralis major between fast‐growing broilers (FG) and slow‐growing layers (SG) identifies the transcriptional factor CREM as a novel brake of myofiber hypertrophy. Mechanistically, functional validation experiments confirm that CREM activates the promoter of JUN and CREM deletion ...
Shuang Gu, Xiyu Zhao, Zheyi Jiang, Chaoliang Wen, Chaoyi Wang, Qiulian Wang, Qiang Huang, Fangren Lan, Shenghui Wu, Junying Li, Congjiao Sun, Huadong Yin, Ning Yang   +12 more
wiley   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

Care of the patient with cardiac arrhythmias

, 2022
Chapter 7: this chapter discusses the care of patients with cardiac arrhythmias. It describes the different types of arrhythmias, their treatment, and nursing priorities for patient ...
Lee, Geraldine, Norekvål, Tone M., Berg, Selina Kikkkenborg, Fålun, Nina, Fitzsimons, Donna, Angus, Neil, Hendriks, Jeroen; id_orcid   +6 more
core   +1 more source