Results 121 to 130 of about 489,421 (410)

Radiosensitization of calreticulin‐overexpressing human glioma cell line by the polyphenolic acetate 7, 8‐diacetoxy‐4‐methylcoumarin

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background Calreticulin (CRT), an endoplasmic reticulum–resident protein generally overexpressed in cancer cells, is associated with radiation resistance. CRT shows higher transacetylase activity, as shown by us earlier, in the presence of the polyphenolic acetates (like 7, 8‐diacetoxy‐4‐methylcoumarin, DAMC) and modifies the activity of a ...
Amit Verma, Aastha Arora, Anant N Bhatt, Mohan B Arya, Ashok K Prasad, Virinder S Parmar, Bilikere S Dwarakanath   +6 more
wiley   +1 more source

Etiological diagnosis, prognostic significance and role of electrophysiological study in patients with Brugada ECG and syncope. [PDF]

, 2017
BACKGROUND: Syncope is considered a risk factor for life-threatening arrhythmias in Brugada patients. Distinguishing a benign syncope from one due to ventricular arrhythmias is often difficult, unless an ECG is recorded during the episode.
Anselmino, M, Barbonaglia, L, Bergamasco, L, Bianchi, F, Bortnik, M, Carvalho, P, Castagno, D, Cerrato, N, Gaita, F, Giustetto, C, Gribaudo, E, Riccardi, R, Rossetti, G, Ruffino, E, Scrocco, C   +14 more
core   +2 more sources

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source

Development in Prescriptions of Contraindicated and Potentially Harmful QT Interval–Prolonging Drugs in a Large Geriatric Inpatient Cohort From 2011 to 2021

Clinical Pharmacology &Therapeutics, Volume 113, Issue 2, Page 435-445, February 2023., 2023
Regulatory authorities put major emphasis on QT (interval)–prolonging properties of new molecular entities. Product information/Summaries of Product Characteristics (SmPCs) of multiple drugs contain warnings or contraindications regarding QT prolongation, e.g., on coadministration of QT‐prolonging drugs (QT drugs).
Melanie I. Then, Thomas Tümena, Anna Sledziewska, Karl‐Günter Gaßmann, Renke Maas, Martin F. Fromm   +5 more
wiley   +1 more source

Arrhythmias May Hide a Genetic Cardiomyopathy in Left Ventricular Hypertrabeculation in Children: A Single-Center Experience

Children
Background. Left ventricular hypertrabeculation (LVHT) is a myocardial disorder with different clinical manifestations, from total absence of symptoms to heart failure, arrhythmias, sudden cardiac death (SCD), and thromboembolic events. It is challenging
Irma Battipaglia, Nicoletta Cantarutti, Marianna Cicenia, Rachele Adorisio, Virginia Battista, Anwar Baban, Massimo Stefano Silvetti, Fabrizio Drago   +7 more
doaj   +1 more source

Apln-CreERT:mT/mG reporter mice as a tool for sprouting angiogenesis study

BMC Ophthalmology, 2017
Background Angiogenesis is defined as a new blood vessel sprouting from pre-existing vessels, and the sprouting angiogenesis is the start phase of angiogenesis, which is critical for both physiological and pathological processes, such as embryonic ...
Jingjiang Pi, Yu Cheng, Huimin Sun, Xiaoli Chen, Tao Zhuang, Jie Liu, Yixi Li, Huan Chang, Lin Zhang, YuZhen Zhang, Ting Tao   +10 more
doaj   +1 more source

Neurogenic disturbances of cardiac rhythm [PDF]

, 2014
Arrhythmias are disturbances of electrical activation of the heart and are commonly encountered clinical conditions. Although typically associated with cardiac pathology, they have also been described in stroke and epilepsy.
Loh, Daniel, Pullicino, Patrick
core  

Neuraxial modulation for treatment of VT storm. [PDF]

, 2014
In the hyperadrenergic state of VT storm where shocks are psychologically and physiologically traumatizing, suppression of sympathetic outflow from the organ level of the heart up to higher braincenters plays a significant role in reducing the propensity
Shivkumar, Kalyanam, Tung, Roderick
core   +1 more source

Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management

Advanced Science, EarlyView.
Electroactive platforms offer promising applications in cardiac arrhythmia. Based on their energy sources and mechanisms, electroactive platforms are categorized into i) direct electrical stimulation, ii) self‐powered electroactive systems, iii) physical stimuli‐mediated electroactive systems, and iv) conductive systems, and their applications in ...
Juwei Yang, Longfei Li, Yiran Hu, Zhou Li, Wei Hua   +4 more
wiley   +1 more source