Results 141 to 150 of about 224,975 (295)

Small‐Molecule Sarco/Endoplasmic Reticulum Ca2+‐ATPase Activators Reverse Methylglyoxal‐Induced Inhibition through Nonantioxidant Mechanisms

ChemMedChem, EarlyView.
Endoplasmic reticulum (ER) Ca2+ dysregulation drives β‐cell dysfunction under diabetic stressors like methylglyoxal, which inhibits the sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) pump through oxidative modifications. We show that synthetic SERCA activators restore pump activity after methylglyoxal‐induced damage.
Carlos Cruz‐Cortés, Silvia Micháliková, Petronela Rezbáriková, L. Michel Espinoza‐Fonseca, Jana Viskupičová   +4 more
wiley   +1 more source

Identification of a SARS-CoV-2 virus-encoded small non-coding RNA in association with the neurological disorders in COVID-19 patients

Signal Transduction and Targeted Therapy, 2022
Qian Zhao, Qiong Wang, Bing Zhao, Yixing Wang, Jinhui Lü, Yuefan Guo, Xiaoping Zhu, Lu Qian, Shanshan Yu, Lipeng Hao, Zhongmin Liu, Zuoren Yu   +11 more
doaj   +1 more source

Acute Reduction in Blood Flow in the Right Coronary Artery After PCI Facilitates Pacemaker-Induced Ventricular Fibrillation. [PDF]

Ann Noninvasive Electrocardiol
Wu B, Chen Y, Tang J, He J.
europepmc   +1 more source

11Analysis of trigger factors is one of the important point in the management of patients with stable coronary artery disease and high-grade ventricular arrhythmias [PDF]

, 2017
E. A. Ryngach, А. А. Татаринова, Т В Трешкур, Е. V. Shlyakhto   +3 more
openalex   +1 more source

Retrospective, Multicenter Study of Lacosamide to Treat Neonatal Seizures

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Most antiseizure medications (ASMs) are prescribed off label for neonates. Lacosamide's efficacy in infants and availability in intravenous formulation suggest potential utility for neonates. We evaluated the safety and efficacy of lacosamide for neonatal seizures. Methods This 10‐center, retrospective study of neonates with seizures
Alexandra Santana Almansa, Jessica R. Landers, Nicholas S. Abend, Giulia M. Benedetti, Catherine J. Chu, Andrew T. Knox, Shavonne Massey, Steffany Moen, Andrea C. Pardo, Arnold Sansevere, Renée A. Shellhaas, Cameron Thomas, Tammy Tsuchida, Sonya Wang, Bo Zhang, Janet S. Soul   +15 more
wiley   +1 more source

Incidence and Risk Factors for Ventricular Arrhythmias in Patients With Acute Myocardial Infarction Presenting to the Emergency Department. [PDF]

Cureus
Mazhar FA, Rubab S, Haider A, Sami Ullah H, M Tufail Q, Tariq U, Ramzan Z.   +6 more
europepmc   +1 more source

Atrial fibrosis: an obligatory component of arrhythmia mechanisms in atrial fibrillation?

, 2017
Pyotr G. Platonov
openalex   +1 more source

Concentration–QTc Modeling to Support Clinical Development of Fezolinetant

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Fezolinetant is a non‐hormonal, selective neurokinin‐3 receptor antagonist that blocks neurokinin B activation of kisspeptin/neurokinin B/dynorphin neurons to thereby modulate neuronal activity in the thermoregulatory center. Fezolinetant has been approved in many regions, including North America, Europe, Asia, and Australia for the treatment ...
Jace C. Nielsen, Masako Saito, Xuegong Wang, Megumi Iwai, Graeme L. Fraser, Steven Ramael, Jiayin Huang   +6 more
wiley   +1 more source

Lamotrigine in Epilepsy: Safe for the Heart after All? [PDF]

Epilepsy Curr
Taraschenko O.
europepmc   +1 more source

Amiodarone for arrhythmia in patients with Chagas disease: A systematic review and individual patient data meta-analysis

, 2018
Cinara Stein, Celina Borges Migliavaca, Verônica Colpani, Priscila Raupp da Rosa, Daniel Sganzerla, Natalia Elis Giordani, Sandro René Pinto de Sousa Miguel, Luciane Nascimento Cruz, Carísi Anne Polanczyk, Antônio Luiz Pinho Ribeiro, Maicon Falavigna   +10 more
openalex   +2 more sources