Results 1 to 10 of about 18,949 (171)

Periostin-CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy. [PDF]

Adv Sci (Weinh)
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Wu T, Li R, Zhang X, Chen D, Yang J, Li M, Yin Y, Wang Y, Tian Y, Yan H, Cui D, Song J, Ouyang G.   +12 more
europepmc   +2 more sources

Multimodality imaging in arrhythmogenic cardiomyopathy [PDF]

Romanian Journal of Cardiology, 2021
Arrhythmogenic cardiomyopathy, as it has been recently redefined, is characterized by progressive myocyte loss with fibrosis and fat infiltration of the myocardium, which finally leads to a broad clinical spectrum ranging from heart failure symptoms to ...
Laura Tapoi, Alexandra Clement, Rodica Radu, Radu Sascau   +3 more
doaj   +1 more source

Biventricular arrhythmogenic cardiomyopathy diagnosed in a young patient: A case report with literature review

Radiology Case Reports, 2023
Arrhythmogenic cardiomyopathy is a genetic heart muscle disease that typically affects the right ventricle. However, 2 other phenotypes affecting the left ventricle were recently discovered.
Hajar El Ouartassi, MD, Raid Faraj, MD, Zakariae Laraichi, MD, Rhita Ezzahraoui, MD, Zaineb Bourouhou, MD, Nawal Doghmi, PhD, Mohamed Cherti, PhD   +6 more
doaj   +1 more source

Generation of human iPSC line from an arrhythmogenic cardiomyopathy patient with a DSP protein-truncating variant

Stem Cell Research, 2023
Arrhythmogenic cardiomyopathy is an inheritable heart disease characterized by lethal heart rhythms and abnormal contractile function. Mutations in desmoplakin (DSP), a protein linking the cardiac desmosome with intermediate filaments, are associated ...
Alexander Loiben, Clayton E. Friedman, Wei-Ming Chien, April Stempien-Otero, Shin Lin, Kai-Chun Yang   +5 more
doaj   +1 more source

Left Ventricular Dysfunction in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC): Can We Separate ARVC From Other Arrhythmogenic Cardiomyopathies?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Arrhythmogenic right ventricular cardiomyopathy was first described as a right ventricular disease that is an important cause of death in young adults. However, with the advent of advanced imaging, arrhythmogenic right ventricular cardiomyopathy has been
Stephan Altmayer, Saman Nazarian, Yuchi Han   +2 more
doaj   +1 more source

Arrhythmogenic Cardiomyopathy—Further Insight into the Clinical Spectrum of Desmoplakin Disease

Cardiogenetics, 2021
Arrhythmogenic cardiomyopathy is a familial heart muscle disease characterized by structural, electrical, and pathological abnormalities. Recognition of left ventricular (LV) involvement in arrhythmogenic right ventricular cardiomyopathy (ARVC) has led ...
Joanne Simpson, Joan Anusas, Denise Oxnard, Sylvia Wright, Ruth McGowan, Caroline Coats   +5 more
doaj   +1 more source

Genetic Animal Models for Arrhythmogenic Cardiomyopathy

Frontiers in Physiology, 2020
Arrhythmogenic cardiomyopathy has been clinically defined since the 1980s and causes right or biventricular cardiomyopathy associated with ventricular arrhythmia.
Brenda Gerull, Brenda Gerull, Andreas Brodehl   +2 more
doaj   +1 more source

Establishment of a Dedicated Inherited Cardiomyopathy Clinic: From Challenges to Improved Patients’ Outcome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Inherited cardiomyopathies (ICs) are relatively rare. General cardiologists have little experience in diagnosing and managing these conditions. International societies have recognized the need for dedicated IC clinics.
Emily Smith, Paul D. Thompson, Carolyn Burke‐Martindale, Adaya Weissler‐Snir   +3 more
doaj   +1 more source

Myocarditis-like Episodes in Patients with Arrhythmogenic Cardiomyopathy: A Systematic Review on the So-Called Hot-Phase of the Disease

Biomolecules, 2022
Arrhythmogenic cardiomyopathy (ACM) is a genetically determined myocardial disease, characterized by myocytes necrosis with fibrofatty substitution and ventricular arrhythmias that can even lead to sudden cardiac death.
Riccardo Bariani, Ilaria Rigato, Alberto Cipriani, Maria Bueno Marinas, Rudy Celeghin, Cristina Basso, Domenico Corrado, Kalliopi Pilichou, Barbara Bauce   +8 more
doaj   +1 more source

Familial screening in case of acute myocarditis reveals inherited arrhythmogenic left ventricular cardiomyopathies

ESC Heart Failure, 2020
Aims Several data suggest that acute myocarditis could be related to genetic variants involved in familial cardiomyopathies, particularly arrhythmogenic cardiomyopathy, but the management of patients with acute myocarditis and their families regarding ...
Nicolas Piriou, Lara Marteau, Florence Kyndt, Jean Michel Serfaty, Claire Toquet, Laurianne Le Gloan, Karine Warin‐Fresse, Damien Guijarro, Thierry Le Tourneau, Emilie Conan, Aurélie Thollet, Vincent Probst, Jean‐Noël Trochu   +12 more
doaj   +1 more source