Results 111 to 120 of about 339,172 (313)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
THE TOHOKU TSUNAMI OF 11 MARCH 2011 AS RECORDED ON THE RUSSIAN FAR EAST [PDF]
Science of Tsunami Hazards, 2012 The source region of the catastrophic Tohoku tsunami of 11 March 2011 was near the Russian Far East, thus a warning was issued for threatened coasts of the Kuril Islands and Kamchatka.
G. V. Shevchenko, T. N. Ivelskaya
doaj
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
On a batch arrival queuing system equipped with a stand-by server during vacation periods or the repairs times of the main server [PDF]
, 2011 We study a queuing system which is equipped with a stand-by server in addition to the main server. The stand-by server provides service to customers only during the period of absence of the main server when either the main server is on a vacation or it ...
Lukas, CA +6 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Stability criteria for controlled queueing networks [PDF]
, 2006 We give criteria for the stability of a very general queueing model under different levels of control. A complete classification of stability (or positive recurrence), transience and null-recurrence is presented for the two queue model. The stability and
Müller, Lisa Johanna
core
Temporal moments of a tracer pulse in a perfectly parallel flow system
, 2002 Perfectly parallel groundwater transport models partition water flow into isolated one-dimensional stream tubes which maintain total spatial correlation of all properties in the direction of flow.
W. E. Bardsley, Bardsley, W. Earl
core +1 more source
Updating Measures of CME Arrival Time Errors
Space WeatherCoronal mass ejections (CMEs) drive space weather effects at Earth and the heliosphere. Predicting their arrival is a major part of space weather forecasting.
C. Kay +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source