Results 241 to 250 of about 67,640 (303)
FEBS Open Bio, EarlyView.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
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Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
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FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
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Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
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Clinical Obstetrics & Gynecology, 2023
Timing of delivery such that maternal and perinatal outcomes are optimized is among the most important and commonplace decisions in obstetric care. Given the importance of this determination, it is somewhat surprising that there has been, until relatively recently, little in the way of high-quality evidence to guide obstetric clinicians in this ...
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Timing of delivery such that maternal and perinatal outcomes are optimized is among the most important and commonplace decisions in obstetric care. Given the importance of this determination, it is somewhat surprising that there has been, until relatively recently, little in the way of high-quality evidence to guide obstetric clinicians in this ...
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Journal of Optimization Theory and Applications, 2005
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Fan, Y. Y., Kalaba, R. E., Moore, J. E.
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zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Fan, Y. Y., Kalaba, R. E., Moore, J. E.
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Science, 2020
New evidence points to a clash between two ancient Mesoamerican cultures, Teotihuacan and the Maya.
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New evidence points to a clash between two ancient Mesoamerican cultures, Teotihuacan and the Maya.
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Information Systems Security, 2001
The first half of 2001 saw the emergence of a new breed of service provider, namely the MSP or Managed Security Provider.
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The first half of 2001 saw the emergence of a new breed of service provider, namely the MSP or Managed Security Provider.
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Medical Journal of Australia, 2001
As the small jet circled the dirt landing strip, I felt apprehensive. The briefing in Nairobi had been very detailed but hadn't really allayed my fears. I struggled with my emotions and too many unanswerable questions. Why was I going to Somalia in the middle of a civil war, a war about which I knew so very little?
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As the small jet circled the dirt landing strip, I felt apprehensive. The briefing in Nairobi had been very detailed but hadn't really allayed my fears. I struggled with my emotions and too many unanswerable questions. Why was I going to Somalia in the middle of a civil war, a war about which I knew so very little?
openaire +2 more sources