Results 71 to 80 of about 3,334,012 (298)
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Cosmological arrow of time in f(R) gravity [PDF]
arXiv, 2016 The cosmological arrow of time may be linked to the thermodynamic arrow by second law of thermodynamics. The time asymmetry is also associated with dissipative fluid as Tolman introduced a viscous fluid to generate an arrow of time in cyclic cosmology.
arxiv
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
The Arrow of Time in Rigged Hilbert Space Quantum Mechanics [PDF]
arXiv, 2005 Arno Bohm and Ilya Prigogine's Brussels-Austin Group have been working on the quantum mechanical arrow of time and irreversibility in rigged Hilbert space quantum mechanics. A crucial notion in Bohm's approach is the so-called preparation/registration arrow. An analysis of this arrow and its role in Bohm's theory of scattering is given.
arxiv
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Does a Computer have an Arrow of Time? [PDF]
, 2007 In [Sch05a], it is argued that Boltzmann's intuition, that the psychological arrow of time is necessarily aligned with the thermodynamic arrow, is correct. Schulman gives an explicit physical mechanism for this connection, based on the brain being representable as a computer, together with certain thermodynamic properties of computational processes ...
arxiv +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Program for the Special State Theory of Quantum Measurement
Entropy, 2017 Establishing (or falsifying) the special state theory of quantum measurement is a program with both theoretical and experimental directions. The special state theory has only pure unitary time evolution, like the many worlds interpretation, but only has ...
Lawrence S. Schulman
doaj +1 more source
Entanglement and the thermodynamic arrow of time [PDF]
Physical Review E, 2010 10 pages with 9 ...
Jennings, D, Rudolph, T
openaire +4 more sources
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source