Results 51 to 60 of about 576,496 (275)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Inadvertent - Ars accidentalis [PDF]
, 2008 Even though art is the product of an intentional act of fabrication, the serendipitous spill of an ink or paint, the unforeseen slip of a pen or brush, sudden shake of a camera in the analog realm have the potential of generating an unconscious lead in ...
Germen, Murat
core
Temporal and Periodic Variations of Sunspot Counts in Flaring and Non-flaring Active Regions
, 2017 We analyzed temporal and periodic behavior of sunspot counts (SSCs) in flaring (C, M, or X class flares), and non-flaring active regions (ARs) for the almost two solar cycles (1996 through 2016).
Donmez, B. +5 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The effect of atmospheric rivers on cold-season heavy precipitation events in Iran
Journal of Water and Climate Change, 2021 Atmospheric rivers (ARs) as massive and concentrated water vapour paths can have a critical impact on extreme events in arid and semi-arid areas. This study investigated the effect of ARs on heavy precipitation events during the cold, rainy months ...
Neda Esfandiari, Hassan Lashkari
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
eFood, 2021 Alkylresorcinols (ARs), which are phenolic lipids found in wheat bran, have attracted a considerable amount of attention because of their antioxidant properties. However, the mechanism of ARs for regulating neuroprotective activity remains unclear.
Yanyu Zou +7 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Scientific Reports, 2020 A computational method has been developed to distinguish the Klebsiella species serotypes to aid in outbreak surveillance. A reliability score (estimated based on the accuracy of a specific K-type prediction against the dataset of 141 distinct K-types ...
L. Ponoop Prasad Patro +2 more
doaj +1 more source
, 2007 We report measurements of the spin polarization (\textbf{\textit{P}}) of the concentrated magnetic semiconductor EuS using both zero-field and Zeeman-split Andreev reflection spectroscopy (ARS) with EuS/Al planar junctions. The zero-field ARS spectra are
A. F. Andreev +9 more
core +1 more source