Results 61 to 70 of about 619,883 (320)

Recessive aminoacyl-tRNA synthetase disorders: lessons learned from in vivo disease models

open access: yesFrontiers in Neuroscience, 2023
Protein synthesis is a fundamental process that underpins almost every aspect of cellular functioning. Intriguingly, despite their common function, recessive mutations in aminoacyl-tRNA synthetases (ARSs), the family of enzymes that pair tRNA molecules ...
Elizabeth Kalotay   +4 more
doaj   +1 more source

Inadvertent - Ars accidentalis [PDF]

open access: yes, 2008
Even though art is the product of an intentional act of fabrication, the serendipitous spill of an ink or paint, the unforeseen slip of a pen or brush, sudden shake of a camera in the analog realm have the potential of generating an unconscious lead in ...
Germen, Murat
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Genesis Locations of the Costliest Atmospheric Rivers Impacting the Western United States

open access: yesGeophysical Research Letters, 2021
Atmospheric rivers (ARs) are responsible for the vast majority (∼88%) of flood damage in the Western U.S., an annual average of USD$1.1 billion. Here, using historical flood insurance data, we investigate the genesis characteristics of damaging ARs in ...
Hamish D. Prince   +7 more
doaj   +1 more source

The effect of atmospheric rivers on cold-season heavy precipitation events in Iran

open access: yesJournal of Water and Climate Change, 2021
Atmospheric rivers (ARs) as massive and concentrated water vapour paths can have a critical impact on extreme events in arid and semi-arid areas. This study investigated the effect of ARs on heavy precipitation events during the cold, rainy months ...
Neda Esfandiari, Hassan Lashkari
doaj   +1 more source

Different contributions to space weather and space climate from different big solar active regions [PDF]

open access: yes, 2019
The purpose of this paper is to show that large active regions (ARs) with different magnetic configurations have different contributions to short-term and long-term variations of the Sun. As a case study, the complex $\delta$-type AR 12673 and the simple
Baranyi, Tunde   +3 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Neuroprotective Effect of Alkylresorcinols from Wheat Bran in HT22 Cells: Correlation with in vitro Antioxidant Activity

open access: yeseFood, 2021
Alkylresorcinols (ARs), which are phenolic lipids found in wheat bran, have attracted a considerable amount of attention because of their antioxidant properties. However, the mechanism of ARs for regulating neuroprotective activity remains unclear.
Yanyu Zou   +7 more
doaj   +1 more source

Fish assemblages associated with three types of artificial reefs: density of assemblages and possible impacts on adjacent fish abundance [PDF]

open access: yes, 2010
We evaluated the effectiveness of wooden artificial reefs (ARs) as fish habitat. Three types of ARs, made of cedar logs, broadleaf tree logs, and PVC pipes, respectively, were deployed in triplicate at 8-m depth off Maizuru, Kyoto Prefecture, Sea of ...
Kai, Yoshiaki   +7 more
core  

Acute radiation syndrome (ARS) – treatment of the reduced host defense

open access: yesInternational Journal of General Medicine, 2012
Background The current radiation threat from the Fukushima power plant accident has prompted rethinking of the contingency plan for prophylaxis and treatment of the acute radiation syndrome (ARS).
L. Heslet   +2 more
semanticscholar   +1 more source

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