Results 81 to 90 of about 619,883 (320)
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Constituindo as listas de espera para cirurgia um problema na prestação de cuidados médicos nos países mais desenvolvidos é importante que se conheça, e perceba, a realidade que enquadra esta problemática de forma a melhorar o processo de ...
CÂNDIDA MACHADO , ALCINA NUNES
doaj
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
NOTION OF LAW IN CLASSICAL ROMAN DOCTRINE; MERELY HISTORY OR ALSO A CHALLENGE?
Roman classical legal doctrine, according to pre-classical thought, ties the notion of law to that which is good and which assures equality of citizens and equitable order of their relations.
Antun Malenica
doaj
Alizarin red S (ARS) was confined in layer-by-layer (LbL) films composed of phenylboronic acid-modified poly(ethyleneimine) (PBA-PEI) and carboxymethylcellulose (CMC) to study the voltammetric response to diol and polyol compounds.
Shigehiro Takahashi +4 more
doaj +1 more source
We report measurements of the spin polarization (\textbf{\textit{P}}) of the concentrated magnetic semiconductor EuS using both zero-field and Zeeman-split Andreev reflection spectroscopy (ARS) with EuS/Al planar junctions. The zero-field ARS spectra are
A. F. Andreev +9 more
core +1 more source
Au Moyen Âge, la Musique chante l'unité du savoir et de l'être. Quand, au XIV e siècle, être et savoir se distancient l'un de l'autre, entraînant avec eux théorie et pratique, matière et forme, la «littérature» émergente joue un rôle d'articulation entre ces dichotomies.
openaire +2 more sources
TMC4 localizes to multiple taste cell types in the mouse taste papillae
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
De novo assembly of the cattle reference genome with single-molecule sequencing
Background Major advances in selection progress for cattle have been made following the introduction of genomic tools over the past 10–12 years. These tools depend upon the Bos taurus reference genome (UMD3.1.1), which was created using now-outdated ...
B. Rosen +32 more
semanticscholar +1 more source
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source

