Results 81 to 90 of about 619,883 (320)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

ESTUDO DO PERÍODO DE PERMANÊNCIA NAS LISTAS DE ESPERA NACIONAIS POR CIRURGIA – APLICAÇÃO DA ANÁLISE DE DURAÇÃO NÃO PARAMÉTRICA POR ARS

open access: yesTourism & Management Studies, 2012
Constituindo as listas de espera para cirurgia um problema na prestação de cuidados médicos nos países mais desenvolvidos é importante que se conheça, e perceba, a realidade que enquadra esta problemática de forma a melhorar o processo de ...
CÂNDIDA MACHADO , ALCINA NUNES
doaj  

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

open access: yesFEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito   +3 more
wiley   +1 more source

NOTION OF LAW IN CLASSICAL ROMAN DOCTRINE; MERELY HISTORY OR ALSO A CHALLENGE?

open access: yesZbornik Radova Pravnog Fakulteta u Splitu, 2006
Roman classical legal doctrine, according to pre-classical thought, ties the notion of law to that which is good and which assures equality of citizens and equitable order of their relations.
Antun Malenica
doaj  

Voltammetric Response of Alizarin Red S-Confined Film-Coated Electrodes to Diol and Polyol Compounds: Use of Phenylboronic Acid-Modified Poly(ethyleneimine) as Film Component

open access: yesSensors, 2018
Alizarin red S (ARS) was confined in layer-by-layer (LbL) films composed of phenylboronic acid-modified poly(ethyleneimine) (PBA-PEI) and carboxymethylcellulose (CMC) to study the voltammetric response to diol and polyol compounds.
Shigehiro Takahashi   +4 more
doaj   +1 more source

Measurement of the spin polarization of the magnetic semiconductor EuS with zero-field and Zeeman-split Andreev reflection spectroscopy

open access: yes, 2007
We report measurements of the spin polarization (\textbf{\textit{P}}) of the concentrated magnetic semiconductor EuS using both zero-field and Zeeman-split Andreev reflection spectroscopy (ARS) with EuS/Al planar junctions. The zero-field ARS spectra are
A. F. Andreev   +9 more
core   +1 more source

Ars poetica. Ars poesis [PDF]

open access: yesÉtudes littéraires, 2005
Au Moyen Âge, la Musique chante l'unité du savoir et de l'être. Quand, au XIV e siècle, être et savoir se distancient l'un de l'autre, entraînant avec eux théorie et pratique, matière et forme, la «littérature» émergente joue un rôle d'articulation entre ces dichotomies.
openaire   +2 more sources

TMC4 localizes to multiple taste cell types in the mouse taste papillae

open access: yesFEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata   +6 more
wiley   +1 more source

De novo assembly of the cattle reference genome with single-molecule sequencing

open access: yesGigaScience, 2020
Background Major advances in selection progress for cattle have been made following the introduction of genomic tools over the past 10–12 years. These tools depend upon the Bos taurus reference genome (UMD3.1.1), which was created using now-outdated ...
B. Rosen   +32 more
semanticscholar   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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