Results 201 to 210 of about 103,218 (267)

ZnO and rGO-Based nanoparticles regulate morphophysiological, biochemical, and molecular responses of Phaseolus vulgaris L. under drought and arsenic stress. [PDF]

BMC Plant Biol
Aygören AS, Uçar S, Yaprak E, Öner BM, Çepni E, Kasapoğlu AG, Buttanrı A, Güneş C, Güneş A, İlhan E, Aydın M.   +10 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Methanogenesis couples with arsenic methylation in urban interface biofilms under arsenic-phosphorus decoupling stress. [PDF]

Front Microbiol
Zheng B, Lei Y, Lin Y, Zhou M, Bi Q.
europepmc   +1 more source

Localised Autophagy Inhibition by Nanodiamonds Potentiates Arsenic Therapy With Favourable Safety Profile in Solid Tumours

Cell Proliferation, EarlyView.
This study presents an NDs‐mediated localised combination strategy that integrates autophagy inhibition with low‐dose ATO sensitization, enabling effective tumour suppression while enhancing safety. NDs‐mediated autophagy blockade enhances ATO efficacy while minimising systemic toxicity, highlighting a promising approach for solid tumour treatment ...
Yiliu Wang, Zhifen Cui, Jichao Zhang, Shitai Zhu, Linjie Guo, Qisheng Wang, Ying Zhu, Shihua Luo, Huating Kong   +8 more
wiley   +1 more source

Enhanced Renoprotective Effects of Morin-Loaded PLGA Nanoparticles Against Arsenic-Induced Kidney Injury in Rats: Amelioration of Oxidative Stress, Inflammation, Fibrosis, and Apoptosis. [PDF]

Pharmaceuticals (Basel)
Aldaghmi AS, Elmorsy EM, Alshammari F, Duhduh A, Aly NM, Habotta OA, Fawzy MS, Shehata SA.   +7 more
europepmc   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Arsenic detoxification within thermo-alkaline biofilms. [PDF]

Front Microbiol
Cooper G, Ayotte SH, Du ML, Wood JD, Opp B, Bothner B, Peyton BM.   +6 more
europepmc   +1 more source

Eusocial bee species are exposed to different toxic element profiles despite foraging within the same landscape

Ecological Entomology, EarlyView.
Bombus terrestris and Apis mellifera colonies sharing the same landscape (<50 m from each other) collected pollen with significantly different heavy metal concentrations. B. terrestris‐collected pollen contained 2–7× higher concentrations of arsenic, chromium, cobalt, lead and tin than A. mellifera‐collected pollen.
Sarah B. Scott, Nynke Blömer, Lynn V. Dicks   +2 more
wiley   +1 more source

Disinfection Byproducts and Inorganic Contaminants in the U.S. Correctional Facility Public Water Systems. [PDF]

Environ Justice
Bannon E, Lieberman-Cribbin W, Spriggs R, Adkins-Jackson PB, Van Horne YO, Parks RM, Prins SJ, Nigra AE.   +7 more
europepmc   +1 more source

Feasibility and Safety of Venetoclax for Cytoreduction During Induction Therapy in Newly Diagnosed Acute Promyelocytic Leukemia

European Journal of Haematology, EarlyView.
ABSTRACT Objective This study aimed to evaluate the feasibility and safety of venetoclax as a cytoreductive strategy during induction therapy in newly diagnosed acute promyelocytic leukemia (APL), and to provide an exploratory description of its early efficacy.
Yu Wang, Rong Xiao, Xiaobing Huang, Yi Xiao   +3 more
wiley   +1 more source