Results 201 to 210 of about 330,749 (304)

Effects of maternal arsenic exposure on birth outcomes using harmonized data across three birth cohorts. [PDF]

Toxicol Environ Health Sci
Feric Z, Beene D, Signes-Pastor AJ, Watkins DJ, Gao G, Karagas MR, MacKenzie DA, Kaeli DR, Manjourides J.   +8 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Mitigating combined toxic effects of arsenic, ammonia, and high temperature through dietary Iron in fish. [PDF]

Front Immunol
Kumar N, Kumar P, Reddy KS.
europepmc   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Skin lesions associated with chronic exposure to arsenic in drinking water in rural Western Iran. [PDF]

Sci Rep
Rahmani A, Khamutian S, Samiee F, Nourian S, Khezrian M, Safari S, Doosti-Irani A, Aleseyyed SB, Saatchi O, Rafati L.   +9 more
europepmc   +1 more source

Outbreak of poisoning by sodium hydrogen methylarsonate (MSMA)—an arsenic‐based herbicide—in horses in Brazil

Equine Veterinary Journal, EarlyView.
Abstract Background Arsenic poisoning in horses is rarely reported in the literature. However, arsenic compounds can be present in rodenticides, pesticides, and herbicides, representing a potential source of accidental exposure for horses. Objective To describe the epidemiological, clinical, and laboratory findings from a herd of 31 horses exposed to ...
Gabriella Faria Pereira, Maria Clara Hornich Blimbliem, Anna Laura Previato Rosa Machado, Junara Bianca Rosa Abdala, Geison Morel Nogueira, Hugo Shisei Toma, Tatiane Furtado de Carvalho, Diego José Zanzarini Delfiol   +7 more
wiley   +1 more source

Persistent effects of early-life arsenic exposure in <i>Caenorhabditis elegans</i>.

Environ Sci Process Impacts
Hershberger KA, Gaballah S, He BJ, Zhang L, Barefoot-Gautier E, Reed CB, Rivera NA, Hsu-Kim H, Meyer JN.   +8 more
europepmc   +1 more source

Rafts of change: microbial and functional dynamics in simulated <i>Sargassum</i> strandings. [PDF]

Appl Environ Microbiol
Nandi S, Stephens TG, Garcia R, Sánchez-García M, Roberson LM, Avalos JL, Chundawat SPS, Bhattacharya D.   +7 more
europepmc   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source