Results 11 to 20 of about 11,432 (188)
ESC Heart Failure, Volume 10, Issue 5, Page 2998-3010, October 2023., 2023 Abstract Aims Impaired myocardial energy homeostasis plays an import role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Left ventricular relaxation has a high energy demand, and left ventricular diastolic dysfunction has been related to impaired energy homeostasis.
Arno A. van de Bovenkamp +10 more
wiley +1 more source
Immunity, Inflammation and Disease, Volume 11, Issue 9, September 2023., 2023 CD4+ T cells decrease in elderly and frailty SCAP patients, which indicates a worse outcome. CD4+ T cells combined with PCT are powerful prognostic biomarkers in evaluating the severity of community‐acquired pneumonia. Abstract Backgrounds Elderly and frailty individuals show a more senescent immune system, which may relate to worse outcome in ...
Jue Wang +8 more
wiley +1 more source
Clinical Case Reports, Volume 11, Issue 3, March 2023., 2023 Abstract The aim of this article is to demonstrate extreme interindividual variability of piperacilin/tazobactam (PIP/TAZO) pharmacokinetics in critically ill morbidly obese patients and to emphasize the need for the practice of routine PIP/TAZO plasma concentrations measurement in order to ensure optimal efficacy and safety of antibiotic therapy.
M. Mieresova +4 more
wiley +1 more source
Superficial temporal artery access for carotid artery stenting: A case report
Clinical Case Reports, Volume 11, Issue 2, February 2023., 2023 Abstract Percutaneous intervention of patients who suffer from generalized vascular disease is often a great challenge due to the limited accessibility of the access gates. We discuss the case of a 66‐year‐old man who presented with critical right internal carotid artery (ICA) stenosis after previous hospitalization due to stroke.
Ádám Csavajda +3 more
wiley +1 more source
Vascular calcification: Molecular mechanisms and therapeutic interventions
MedComm, Volume 4, Issue 1, February 2023., 2023 Vascular calcification is caused by the imbalance of vascular microenvironment. The pro‐calcific factors include chronic inflammation, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, iron homeostasis, programed cell death, and other cellular metabolic dynamics.
Wei Pan, Wei Jie, Hui Huang
wiley +1 more source
Human Mutation, Volume 43, Issue 12, Page 1824-1828, December 2022., 2022 Abstract Pathogenic variants in JAG1 are known to cause Alagille syndrome (ALGS), a disorder that primarily affects the liver, lung, kidney, and skeleton. Whereas cardiac symptoms are also frequently observed in ALGS, thoracic aortic aneurysms have only been reported sporadically in postmortem autopsies.
Jotte Rodrigues Bento +16 more
wiley +1 more source
IET Nanobiotechnology, Volume 16, Issue 9, Page 316-324, December 2022., 2022 Abstract A lack of angiogenesis is the key problem in the healing of diabetic foot ulcers. Stem cells have already been proven to have a high potential for angiogenesis. The most important aspects of stem cell therapy are improving the microenvironment, cell homing and continuous factor stimulation.
Rui Tang +3 more
wiley +1 more source
Diversity in the bone marrow niche: Classic and novel strategies to uncover niche composition
British Journal of Haematology, Volume 199, Issue 5, Page 647-664, December 2022., 2022 Summary Our view on the role and composition of the bone marrow (BM) has dramatically changed over time from a simple nutrient for the bone to a highly complex multicellular tissue that sustains haematopoiesis. Among these cells, multipotent haematopoietic stem cells (HSCs), which are predominantly quiescent, possess unique self‐renewal capacity and ...
Raúl Sánchez‐Lanzas +2 more
wiley +1 more source
Clinical and Translational Science, Volume 15, Issue 12, Page 2918-2927, December 2022., 2022 Abstract Abrupt return to normothermia has been shown a genuine factor contributing to graft dysfunction after transplantation. This study tested the concept to mitigate reperfusion injury of liver grafts by gentle warming‐up using ex vivo machine perfusion prior to reperfusion.
Thomas Minor +8 more
wiley +1 more source
Artificial Organs, Volume 46, Issue 9, Page 1783-1793, September 2022., 2022 Kidneys underwent EVNP for 2h with plasma‐like solution with or without A‐AOCs in different volume fractions (0, 2, 4 or 8%). The oxygen gradient along the nephron, cell death, GFR and oxidative stress was improved in the 4% group compared to the 0%, 2%, and 8% group. Abstract Introduction Organ preservation through ex‐vivo normothermic perfusion (EVNP)
Johannes Jägers +4 more
wiley +1 more source