Results 31 to 40 of about 14,637,537 (49)

Mercury 4.0: from visualization to analysis, design and prediction

open access: yesJournal of Applied Crystallography, 2020
An overview of Mercury 4.0, an analysis, design and prediction platform that acts as a hub for the entire Cambridge Structural Database software suite, is presented.
C. Macrae   +10 more
semanticscholar   +1 more source

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

open access: yesPhysical Review Letters
On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven" (or G_{target}>1) where 2.05 MJ of ...
H. Abu-Shawareb   +499 more
semanticscholar   +1 more source

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

open access: yesScience, 2020
The genetics underlying severe COVID-19 The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs).
P. Bastard   +98 more
semanticscholar   +1 more source

Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

open access: yesThe Lancet, 2020
Summary Background Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are ...
Christopher J L Aleksandr Y Peng Cristiana Kaja M Mohsen Foad Murray Aravkin Zheng Abbafati Abbas Abbasi-Kangeva   +499 more
semanticscholar   +1 more source

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

open access: yesNature Microbiology, 2020
The present outbreak of a coronavirus-associated acute respiratory disease called coronavirus disease 19 (COVID-19) is the third documented spillover of an animal coronavirus to humans in only two decades that has resulted in a major epidemic.
Alexander E. Susan C. Ralph S. Raoul J. Christian Anastasia Gorbalenya Baker Baric de Groot Drosten Gulyaeva H   +17 more
semanticscholar   +1 more source

RoB 2: a revised tool for assessing risk of bias in randomised trials

open access: yesBritish medical journal, 2019
Assessment of risk of bias is regarded as an essential component of a systematic review on the effects of an intervention. The most commonly used tool for randomised trials is the Cochrane risk-of-bias tool. We updated the tool to respond to developments
J. Sterne   +27 more
semanticscholar   +1 more source

INFOGEST static in vitro simulation of gastrointestinal food digestion

open access: yesNature Protocols, 2019
Developing a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract.
A. Brodkorb   +34 more
semanticscholar   +1 more source

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

open access: yesNew England Journal of Medicine, 2019
BACKGROUND The cardiovascular safety profile of dapagliflozin, a selective inhibitor of sodium–glucose cotransporter 2 that promotes glucosuria in patients with type 2 diabetes, is undefined. METHODS We randomly assigned patients with type 2 diabetes who
S. Wiviott   +20 more
semanticscholar   +1 more source

Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050

open access: yesi Medicina
Summary Background This study aims to estimate the burden, trends, forecasts, and disparities of early musculoskeletal (MSK) disorders among individuals ages 15 to 39 years.
Yingzhao Jin   +456 more
semanticscholar   +1 more source

Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

open access: yesNature, 2021
E. Volz   +499 more
semanticscholar   +1 more source

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