Results 31 to 40 of about 55,783 (261)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Miranda: Revue Pluridisciplinaire du Monde AnglophoneAll objects are, by nature, mobile, but some are even more so than others because their long migrations push them towards new forms, give them a different status or involve sometimes unexpected uses.
Sabine du Crest
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Czech (Post)Socialist DIY-Material Culture as Vernacular Art: Inscribed Narratives and Their Urban Materialisation [PDF]
Studia Ethnologica Pragensia, 2020 The aim of this paper is to rethink the narratives surrounding Czech (post)socialist Do-It-Yourself material culture (DIY) and to explore how it has become a medium for symbolic expression in urban and rural spaces after the (post)socialist ...
Tereza Hodúlová
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Médiations & Médiatisations, 2022 Résumé Nous nous intéressons au développement professionnel des enseignants stagiaires dans une formation à distance, via une plateforme e-space qui apparait comme un hub social et éducatif (Gobert, 2009, 2020).
Latifa Rebah
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Examining the Philosophical Underpinnings of Design Science Research (DSR)
PhilosophiesDesign science research (DSR) has become a popular method in information systems research and has been warmly welcomed in other disciplines as well. The importance of DSR is evident, in terms of its contribution to knowledge, as well as the creation of ...
Chamara Panakaduwa +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source