Results 41 to 50 of about 55,783 (261)

Neural Network DDoS Mitigation System With Forensic Audit Support for Cyber Police

IEEE Access
The article examines the timely and resource-efficient detection and neutralisation of the distributed DDoS attacks problem while simultaneously ensuring cryptographically reliable artefacting of evidence that meets the forensic suitability requirements.
Serhii Vladov, Lukasz Scislo, Anatoliy Sachenko, Hanna Foros, Dmytro Zhuravlov, Victoria Vysotska, Vitalii Varlakhov, Svitlana Sachenko, Jan Krupinski, Oksana Brusakova   +9 more
doaj   +1 more source

Le « jeu non sérieux », une activité improductive ?

Interfaces Numériques, 2017
Cet article s’inscrit dans la lignée des travaux de Gilles Brougère et vise à étudier le rapport du jeu au sérieux. Sérieux est entendu au sens « utilitaire » comme le propose notamment Étienne Armand Amato.
Julian Alvarez, Aurélien Libessart, Sylvain Haudegond   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Oocyte and embryo culture under oil profoundly alters effective concentrations of small molecule inhibitors

Frontiers in Cell and Developmental Biology
Culture of oocytes and embryos in media under oil is a cornerstone of fertility treatment, and extensively employed in experimental investigation of early mammalian development. It has been noted anecdotally by some that certain small molecule inhibitors
Gaudeline Rémillard-Labrosse, Sydney Cohen, Éliane Boucher, Kéryanne Gagnon, Filip Vasilev, Aleksandar I. Mihajlović, Greg FitzHarris, Greg FitzHarris, Greg FitzHarris   +8 more
doaj   +1 more source

Human hair in contemporary art: conservation issues and solutions

CeROArt : Conservation, Exposition, Restauration d'Objets d'Art, 2017
This study explores the use of human hair in contemporary art threw several artworks from the Belgian artist Hélène de Gottal. She employs the traditional techniques used by spindle lace makers, as well as hairspray, to create masks using her face as a ...
Amélie Pirotte
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Pupil size affects measures of eye position in video eye tracking: implications for recording vergence accuracy

Journal of Eye Movement Research, 2016
Video eye trackers rely on the position of the pupil centre. However, the pupil centre can shift when the pupil size changes. This pupillary artifact is investigated for binocular vergence accuracy (i.e. fixation disparity) in near vision where the pupil
Wolfgang Jaschinski
doaj   +1 more source