Results 61 to 70 of about 397,276 (322)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Hub social et éducatif : formation et transformation des sujets - Appropriation et construction de compétences

Médiations & Médiatisations, 2022
Résumé Nous nous intéressons au développement professionnel des enseignants stagiaires dans une formation à distance, via une plateforme e-space qui apparait comme un hub social et éducatif (Gobert, 2009, 2020).
Latifa Rebah
doaj   +1 more source

ARTeFACT Movement Thesaurus [PDF]

, 2012
The ARTeFACT Movement Thesaurus is a continuation of the ARTeFACT project which was developed at the University of Virginia as a means of enabling research into movement-based arts, specifically dance.
Bradford Bennett, Bradford Bennett
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Examining the Philosophical Underpinnings of Design Science Research (DSR)

Philosophies
Design science research (DSR) has become a popular method in information systems research and has been warmly welcomed in other disciplines as well. The importance of DSR is evident, in terms of its contribution to knowledge, as well as the creation of ...
Chamara Panakaduwa, Paul Coates, Mustapha Munir, Srimal Samansiri   +3 more
doaj   +1 more source

Impact Factor: outdated artefact or stepping-stone to journal certification?

, 2011
A review of Garfield's journal impact factor and its specific implementation as the Thomson Reuters Impact Factor reveals several weaknesses in this commonly-used indicator of journal standing.
A Andrade, A Bonillo Perales, A Coleman, A Fassoulaki, A Lomnicki, A Schubert, A Tal, AI Pudovkin, Anonymous, AP Kurmis, AP Kurmis, AR Weale, AW Jones, AW Jones, B Cashore, B Statzner, B Stiftel, B Timuralp, BD Cameron, BM Althouse, C Chen, C Johnson, C McGarty, C Minelli, C Neuhaus, C Scully, CM Ketcham, CP Robert, CR Bain, CW Holsapple, D Ho, D Leutner, D Poomkottayil, D Schoonbaert, D Ugolini, DB Resnik, DB Resnik, DC Greenwood, DE Drew, DN Laband, DR Smith, DW Straub, E Archambault, E Garfield, E Garfield, E Garfield, E Garfield, E Postma, E Wager, EJ Favaloro, EM Sonderstrup-Andersen, EV Bernstam, F Godlee, F Habibzadeh, F Preti, F-T Krell, FJ Bath, FN Dost, G Abramo, G Jacobs, G Knothe, G Lehmkuhl, G Maier, G Racki, G Walter, G Williams, G Winkmann, G Winkmann, G Yu, G Yu, GE Hunt, H Brown, H Goldstein, H Moed, H Sompel Van de, H Xiao, HB Hansen, HF Moed, I Chalmers, I Hames, J Awrey, J Bollen, J Cheek, J Davies, J Horner, J Kapeller, J Mehrad, J Mehrad, J Moller, J Reedijk, J Roberts, J Schopfel, J Woelfel, JA Dempsey, JB Cohen, Jerome K. Vanclay, JJ Ramsden, JK Vanclay, JL Wulff, JM Campanario, JM Campanario, JM Campanario, JP Skovsgaard, JS Kotiaho, JYA Foo, JYA Foo, K Metze, K Simons, K Soreide, KG Altmann, L Bornmann, L Eaton, L Gollogly, L Leydesdorff, L McKeever, L Rieseberg, L Rieseberg, LL Gluud, LL Lange, M Callaham, M Callaham, M Chew, M Driel Van, M Errami, M Errami, M Frank, M Jahangiriana, M Patterson, M Porter, M Rossner, M Rossner, M Taylor, M-J Johnstone, MA Hernan, MA Ruiz, MC Calver, ME Falagas, ME McVeigh, MF Fox, MJ Cobo, MJ Tobin, MV Simkin, N Haslam, N Rezaei-Ghaleh, N Sombatsompop, N Sombatsompop, P Abraham, P Campbell, P Dong, P Jacso, P Jörgensen, P Owlia, PA Lawrence, PA Todd, PA Todd, PC Gøtzsche, PLoS Medicine Editors, PO Seglen, PO Seglen, PO Seglen, R Adler, R Coleman, R Meneghini, R Rousseau, R Rousseau, R Saunders, R Zetterstrom, RA Brumback, RA Brumback, RJ Epstein, RJ Stein, RP Vlosky, RW Glynn, S Butakov, S Chapman, S Lock, S Meyer zu Eissen, S Saha, S Wang, S Woolgar, SE Gwilym, SJ Bensman, SJ Bensman, SJ Bensman, SL Lau, T Braun, TC Ha, TH Berquist, TL Ogden, TN Leeuwen Van, TP Kurmis, TV Perneger, V Barbour, V Kumar, V Larivière, VA Cartwright, W Glänzel, W Glänzel, W Yue, WH Starbuck, WR Schumm, WT Obremskey   +201 more
core   +1 more source

Spectral filtering as a method of visualising and removing striped artefacts in digital elevation data [PDF]

, 2008
Spectral filtering was compared with traditional mean spatial filters to assess their ability to identify and remove striped artefacts in digital elevation data. The techniques were applied to two datasets: a 100 m contour derived digital elevation model
Albani, Arrell, Arrell, Baltsavias, Bishop, Brocklehurst, Brunson, Champeney, Chen, Christensen, Cooper, Dobrin, Dragut, Felicismo, Fisher, Fisher, Flood, Florinsky, Garbrecht, Guth, Hannah, Hassan, Hengl, Hodgson, Holmes, Hunter, Hutchinson, Jenson, Klinkenberg, Kok, Kumler, Little, Liu, Miliaresis, Moore, Peucker, Pike, Prima, Rayner, Richie, Sithole, Sithole, Su, Temme, Thapa, Walker, Wilson, Wise, Wise, Wise, Wood, Wood   +51 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Neural Network DDoS Mitigation System With Forensic Audit Support for Cyber Police

IEEE Access
The article examines the timely and resource-efficient detection and neutralisation of the distributed DDoS attacks problem while simultaneously ensuring cryptographically reliable artefacting of evidence that meets the forensic suitability requirements.
Serhii Vladov, Lukasz Scislo, Anatoliy Sachenko, Hanna Foros, Dmytro Zhuravlov, Victoria Vysotska, Vitalii Varlakhov, Svitlana Sachenko, Jan Krupinski, Oksana Brusakova   +9 more
doaj   +1 more source

Le « jeu non sérieux », une activité improductive ?

Interfaces Numériques, 2017
Cet article s’inscrit dans la lignée des travaux de Gilles Brougère et vise à étudier le rapport du jeu au sérieux. Sérieux est entendu au sens « utilitaire » comme le propose notamment Étienne Armand Amato.
Julian Alvarez, Aurélien Libessart, Sylvain Haudegond   +2 more
doaj   +1 more source