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Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics
Acta Pharmaceutica Sinica B, 2021 Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treatment of fibrosis.
Pamela J Weathers +2 more
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Pharmacology & Therapeutics, 2020
As the first-line antimalarial drugs, artemisinins gained wide acceptance after the emergence of resistance to chloroquine in the 1950s. Artemisinin-based drugs have saved lives, especially in developing countries. The discovery of artemisinin was unique, timely, and fascinating, and the benefits of artemisinin were with far-reaching implications ...
Nan Ma, Youyou Tu, Tingliang Jiang
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As the first-line antimalarial drugs, artemisinins gained wide acceptance after the emergence of resistance to chloroquine in the 1950s. Artemisinin-based drugs have saved lives, especially in developing countries. The discovery of artemisinin was unique, timely, and fascinating, and the benefits of artemisinin were with far-reaching implications ...
Nan Ma, Youyou Tu, Tingliang Jiang
exaly +3 more sources
2017
Artemisinin, also known as Qinghaosu, is the active principle extract of Qinghao (Artemisia annua L.), a plant that has been used for centuries in traditional Chinese medicine. The antimalarial properties of artemisinin were first reported in the Western literature in 1979 (Jiang et al., 1982).
Thriemer, Kamala +3 more
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Artemisinin, also known as Qinghaosu, is the active principle extract of Qinghao (Artemisia annua L.), a plant that has been used for centuries in traditional Chinese medicine. The antimalarial properties of artemisinin were first reported in the Western literature in 1979 (Jiang et al., 1982).
Thriemer, Kamala +3 more
openaire +4 more sources
Akupunktur & Aurikulomedizin, 2016
Der Pflanzeninhaltsstoff Artemisinin des Einjahrigen Beifus (Artemisia annua) ist durch die Verleihung des Medizinnobelpreises an die chinesische Forscherin Tu Youyou in den Fokus der Offentlichkeit geruckt. Die medizinische Verwendung der Pflanze weist eine lange Tradition auf.
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Der Pflanzeninhaltsstoff Artemisinin des Einjahrigen Beifus (Artemisia annua) ist durch die Verleihung des Medizinnobelpreises an die chinesische Forscherin Tu Youyou in den Fokus der Offentlichkeit geruckt. Die medizinische Verwendung der Pflanze weist eine lange Tradition auf.
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Clinical Microbiology ReviewsSUMMARY The artemisinin antimalarials are the cornerstone of current malaria treatment. The development of artemisinin resistance in Plasmodium falciparum poses a major threat to malaria control and elimination.
Nicholas John White, Kesinee Chotivanich
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Artemisinins: Artemisinin, Dihydroartemisinin, Artemether and Artesunate
2011Artemisinin comes from the plant, Artemisia annua, an ancient Chinese herbal remedy for relapsing fever. Rediscovery of its antimalarial action in China in the 1970s has seen it and its semisynthetic derivatives become the most useful drugs for most malarial illness. Artemisinins have a sesquiterpene lactone structure.
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Artemisinins: activities and actions
Microbes and Infection, 2004Multidrug-resistant malaria caused by Plasmodium falciparum has severely limited treatment options over recent years. Artemisinins are still effective for treating uncomplicated as well as severe malaria, because resistance is not yet clinically apparent. This article reviews some clinically useful properties of artemisinins and how they might work.
Haynes, RK, Krishna, S.
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Artemisinins and immune system
European Journal of Pharmacology, 2011Artemisinins in combination with other antimalarial drugs remain the mainstay of current antimalarial armamentarium. It is interesting to note that many traditional drugs with antiprotozoal background can wield immunomodulation on the recipient's immune system in a positive or negative direction. Artemisinins also attribute immunomodulatory distensions.
Lubna, Shakir +4 more
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An Update on Artemisinin Resistance
2019While the precise mode of action of artemisinin (ART) derivatives remains obscure, it is nonetheless commonly accepted that ART generates reactive oxygen intermediates that contribute to cell death. Also, numerous studies confirm that point mutations in the propeller domain of K13 protein play a key role in resistance to ART derivatives. Because of its
Ariey, Frederic, Ménard, Didier
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Unpacking ‘Artemisinin Resistance’
Trends in Pharmacological Sciences, 2017Artemisinin and its derivatives, in combination with partner drugs, are currently the most effective treatments for malaria parasite infection. Even though artemisinin has been widely used for decades, its mechanism of action had remained controversial until recently.
Jigang, Wang +3 more
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