Results 131 to 140 of about 15,257 (261)
Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions
MedComm, Volume 6, Issue 12, December 2025.A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu +4 more
wiley +1 more source
Characterisation of Early Biosynthetic Steps of Atractylon via an Integrative Strategy
Plant Biotechnology Journal, Volume 23, Issue 12, Page 5728-5744, December 2025.ABSTRACT Atractylodes lancea, a vital medicinal plant, is renowned for its bioactive sesquiterpenoids, particularly atractylon. Despite its therapeutic importance, the genetic and biosynthetic pathways underlying atractylon production remain insufficiently understood.
Juan Zhu +12 more
wiley +1 more source
Screening for K13-Propeller Mutations Associated with Artemisinin Resistance in Plasmodium falciparum in Yambio County (Western Equatoria State, South Sudan) [PDF]
, 2023 Irene Molina‐de la Fuente +11 more
openalex +1 more source
Plant Biotechnology Journal, Volume 23, Issue 12, Page 5817-5832, December 2025.ABSTRACT Salvia miltiorrhiza produces pharmacologically bioactive diterpenoid tanshinones which are regulated by jasmonate (JA) and abscisic acid (ABA) signalling, while their crosstalk in this process remains unclear. Here, we demonstrated that MeJA and ABA acted synergistically to enhance tanshinone biosynthesis.
Tingyao Liu +8 more
wiley +1 more source
The Plant Journal, Volume 124, Issue 5, December 2025.Significance Statement We find the unique evolutionary path of an autotetraploid Artemisia argyi involving gametic chromosome fusion preceding a species‐specific whole‐genome duplication and the functional divergence of an ADS tandem cluster that produces α‐bisabolol instead of the artemisinin precursor amorpha‐4,11‐diene, elucidating the genomic basis
Xinlian Chen +7 more
wiley +1 more source
Efficacy and Safety of Mefloquine, Artesunate, Mefloquine-Artesunate, and Praziquantel against Schistosoma haematobium: Randomized, Exploratory Open-Label Trial [PDF]
, 2017 Background. Morbidity control of schistosomiasis relies on a single drug, praziquantel. The antimalarial drug mefloquine possesses interesting antischistosomal properties, yet no clinical studies have been performed. Methods.
Adoubryn, Koffi D. +7 more
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Artesunate and artemether are effective fasciolicides in the rat model and in vitro [PDF]
, 2017 Objectives: To study the fasciocidal properties of artesunate and artemether in the rat model and in vitro. Methods: Adult Fasciola hepatica were exposed in vitro to 1, 10 and 100 µg/mL of artesunate, artemether and dihydroartemisinin for 72 h.
Keiser, Jennifer +3 more
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, 2013 PURPOSE: It is increasingly common for health care professionals from developed countries to travel to developing regions of the world to learn or teach.
Drain +6 more
core +1 more source
In vitro and in vivo activity of 3-alkoxy-1,2-dioxolanes against Schistosoma mansoni [PDF]
, 2017 Objectives Compounds characterized by a peroxidic skeleton are an interesting starting point for antischistosomal drug discovery. Previously a series of 3-alkoxy-1,2-dioxolanes, which are chemically stable cyclic peroxides, demonstrated significant in ...
Benner, Evan +5 more
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