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Artemisinins: Artemisinin, Dihydroartemisinin, Artemether and Artesunate
, 2011Artemisinin comes from the plant, Artemisia annua, an ancient Chinese herbal remedy for relapsing fever. Rediscovery of its antimalarial action in China in the 1970s has seen it and its semisynthetic derivatives become the most useful drugs for most malarial illness. Artemisinins have a sesquiterpene lactone structure.
H. Karunajeewa
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Artemisinins: Promising drug candidates for the treatment of autoimmune diseases
Medicinal research reviews (Print), 2023Autoimmune diseases are characterized by the immune system's attack on one's own tissues which are highly diverse and diseases differ in severity, causing damage in virtually all human systems including connective tissue (e.g., rheumatoid arthritis ...
Xu Gao +3 more
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Pharmacology & Therapeutics, 2020
As the first-line antimalarial drugs, artemisinins gained wide acceptance after the emergence of resistance to chloroquine in the 1950s. Artemisinin-based drugs have saved lives, especially in developing countries. The discovery of artemisinin was unique, timely, and fascinating, and the benefits of artemisinin were with far-reaching implications ...
Fulong Liao +4 more
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As the first-line antimalarial drugs, artemisinins gained wide acceptance after the emergence of resistance to chloroquine in the 1950s. Artemisinin-based drugs have saved lives, especially in developing countries. The discovery of artemisinin was unique, timely, and fascinating, and the benefits of artemisinin were with far-reaching implications ...
Fulong Liao +4 more
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A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria [PDF]
Nature, 2015 Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance to them raises risk of wiping out recent gains achieved in reducing worldwide malaria burden and threatens future malaria control and elimination on a global ...
Alassane Mbengue +2 more
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Journal of Organic Chemistry, 2020
To achieve both structural changes and rapid synthesis of the tetracyclic scaffold relevant to artemisinins, we explored two kinds of de novo synthetic approaches that generate both skeletally diversified tetracyclic peroxides and 6-aza-artemisinins. The
Karunakar Reddy Bonepally +16 more
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To achieve both structural changes and rapid synthesis of the tetracyclic scaffold relevant to artemisinins, we explored two kinds of de novo synthetic approaches that generate both skeletally diversified tetracyclic peroxides and 6-aza-artemisinins. The
Karunakar Reddy Bonepally +16 more
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Artemisinins—a Promising New Treatment for Systemic Lupus Erythematosus: a Descriptive Review
Current Rheumatology Reports, 2018Chenchen Wang
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Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction
SciencePolycystic ovary syndrome (PCOS), a prevalent reproductive disorder in women of reproductive age, features androgen excess, ovulatory dysfunction, and polycystic ovaries.
Yang Liu +20 more
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An Update on Artemisinin Resistance
2019While the precise mode of action of artemisinin (ART) derivatives remains obscure, it is nonetheless commonly accepted that ART generates reactive oxygen intermediates that contribute to cell death. Also, numerous studies confirm that point mutations in the propeller domain of K13 protein play a key role in resistance to ART derivatives. Because of its
Ariey, Frederic, Ménard, Didier
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Artemisinins: Pharmacological actions beyond anti-malarial
Pharmacology and Therapeutics, 2014W S Fred Wong
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Chemistry of artemisinin: an overview
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994The endoperoxide sesquiterpene lactone, artemisinin, and its derivatives have become increasingly important as antimalarial drugs with impressive activity against multidrug resistant forms of Plasmodium falciparum. Artemisinin has a novel structure among known antimalarial compounds with a unique 1,2,4-trioxane ring that is essential for activity. This
Erich K. Lehnert, H.Kyle Webster
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