Results 111 to 120 of about 6,373 (213)

The peroxidic bridge is essential to the inhibitory activity of artemisinin in both yeast and malaria parasites.

, 2013
(A) Molecular structures of artemisinin and analogues (artemisinins) used in the study. Deoxyartemisinin contains only one O in the otherwise O-O bridge. (B) Inhibition of yeast growth with artemisinins.
Juan Wang (115708), Qiangwang Fan (168416), Ying Li (38224), Bing Zhou (168418), Jian Li (41607), Yicheng Long (366418), Liying Huang (366417)   +6 more
core   +1 more source

A mitochondria-targeting artemisinin derivative with sharply increased antitumor but depressed anti-yeast and anti-malaria activities

, 2017
The potent anti-malarial drug artemisinins are additionally anti-tumorigenic and inhibitory to yeast growth. The action mechanism of artemisinins, however, is not well understood.
Yu Cao, Pan Zhu, Chen Sun, Bing Zhou
core   +1 more source

Repurposing of anti-malarial drugs for the treatment of tuberculosis: realistic strategy or fanciful dead end?

Malaria Journal
Background Drug repurposing offers a strategic alternative to the development of novel compounds, leveraging the known safety and pharmacokinetic profiles of medications, such as linezolid and levofloxacin for tuberculosis (TB).
Thomas Hanscheid, Claire Ruiz del Portal Luyten, Sabine M. Hermans, Martin P. Grobusch   +3 more
doaj   +1 more source

Artemisinins and synthetic trioxolanes in the treatment of helminth infections.

, 2007
PURPOSE OF REVIEW Helminthiases, including schistosomiasis and food-borne trematodiasis, affect millions of people. Just a few drugs are used for the treatment and control of these diseases.
Keiser J, Utzinger J
core   +1 more source

Food-borne trematodiasis: current chemotherapy and advances with artemisinins and synthetic trioxolanes.

, 2007
Over 40 million people are infected with food-borne trematodes and 750 million are at risk of food-borne trematodiasis, and yet this tropical disease is neglected.
Keiser J, Utzinger J
core   +1 more source

Synthetic and mechanistic studies on the mechanism of action of artemisinins

, 2010
Artemisinin, a sesquiterpene peroxide isolated from Artemisia annua, and its derivatives are our most useful antimalarials. Their history, development and clinical efficacy are reviewed.
Li, Ka Yan
core  

Widespread Availability of Artemisinin Monotherapy in the United States

Emerging Infectious Diseases, 2011
Robert M. Rakita, Uma Malhotra
doaj   +1 more source

Expression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor Classes [PDF]

, 2017
Background. The mechanism of action of artemisinins against malaria is unclear, despite their widespread use in combination therapies and the emergence of resistance. Results.
Staines, Henry M., Avery, Mitchell A., Halbert, Jean, Krishna, Sanjeev, Pulcini, Serena, Tewari, Rita, Haynes, Richard K., Shah, Falgun, Doerig, Christian, Pittman, Jon K., Slavic, Ksenija   +10 more
core  

Studies on the molecular mechanism of action of artemisinins

, 2008
The causes and chemotherapies of malaria are briefly discussed. Among those treatments for malaria, artemisinins, the Chinese peroxidic sesquiterpene quinghaosu, is of special interest.
Fan, Kit Man
core  

Intrarectal artemisinin derivatives.

Medecine tropicale : revue du Corps de sante colonial, 1998
The artemisinin derivatives are the most potent antimalarials. They are rapidly absorbed orally, parenterally and intra-rectally. The latter mode of administration is particularly interesting in rural tropics. Preliminary studies have shown that artemisinin and its derivatives artesunate and artemether are effective when given intrarectally.
Nosten, F, van Vugt, M, White, N
openaire   +3 more sources