Results 141 to 150 of about 17,496 (173)

High-Throughput Analysis for Artemisinins with Deep Eutectic Solvents Mechanochemical Extraction and Direct Analysis in Real Time Mass Spectrometry.

Analytical Chemistry, 2018
A fast, simple, efficient, and high-throughput analytical protocol using deep eutectic solvents (DES) for mechanochemical extraction (MCE) combined with direct analysis in real time mass spectrometry (DART-MS) was developed to quantify heat-labile ...
Jiaqin Wang, Yanying Zhou, Man Wang, W. Bi, Hongli Li, D. Chen   +5 more
semanticscholar   +1 more source

ARTEMISININ

Akupunktur & Aurikulomedizin, 2016
Der Pflanzeninhaltsstoff Artemisinin des Einjahrigen Beifus (Artemisia annua) ist durch die Verleihung des Medizinnobelpreises an die chinesische Forscherin Tu Youyou in den Fokus der Offentlichkeit geruckt. Die medizinische Verwendung der Pflanze weist eine lange Tradition auf.
openaire   +2 more sources

Unpacking ‘Artemisinin Resistance’

Trends in Pharmacological Sciences, 2017
Artemisinin and its derivatives, in combination with partner drugs, are currently the most effective treatments for malaria parasite infection. Even though artemisinin has been widely used for decades, its mechanism of action had remained controversial until recently.
Jigang Wang, Jigang Wang, Steven R. Meshnick, Zhao-Rong Lun, Chengchao Xu   +4 more
openaire   +3 more sources

Design and De Novo Synthesis of 6-Aza-artemisinins.

Organic Letters, 2018
Development of designer natural product variants, 6-aza-artemisinins, enabled us to achieve structural modification of the hitherto unexplored cyclohexane moiety of artemisinin and concise de novo synthesis of the tetracyclic scaffold in just four steps ...
Karunakar Reddy Bonepally, Takahisa Hiruma, Haruki Mizoguchi, Kyohei Ochiai, Shun Suzuki, H. Oikawa, Aki Ishiyama, Rei Hokari, M. Iwatsuki, K. Otoguro, Satoshi O mura, H. Oguri   +11 more
semanticscholar   +1 more source

Artemisinins: activities and actions

Microbes and Infection, 2004
Multidrug-resistant malaria caused by Plasmodium falciparum has severely limited treatment options over recent years. Artemisinins are still effective for treating uncomplicated as well as severe malaria, because resistance is not yet clinically apparent. This article reviews some clinically useful properties of artemisinins and how they might work.
Haynes, RK, Krishna, S.
openaire   +4 more sources

Artemisinins target the SERCA of Plasmodium falciparum

Nature, 2003
U. Eckstein-Ludwig, R. Webb, I. V. Goethem, J. East, Anthony G. Lee, M. Kimura, P. O’Neill, P. Bray, S. Ward, S. Krishna   +9 more
exaly   +2 more sources

Artemisinins and immune system

European Journal of Pharmacology, 2011
Artemisinins in combination with other antimalarial drugs remain the mainstay of current antimalarial armamentarium. It is interesting to note that many traditional drugs with antiprotozoal background can wield immunomodulation on the recipient's immune system in a positive or negative direction. Artemisinins also attribute immunomodulatory distensions.
Muzammal Hussain, Muhammad Aqeel Ashraf, Lubna Shakir, Aqeel Javeed, Amjad Riaz   +4 more
openaire   +3 more sources

A Concise Synthesis of (+)-Artemisinin

Journal of the American Chemical Society, 2012
Malaria represents one of the most medically and economically debilitating diseases present in the world today. Fortunately, there exists a highly effective treatment based on the natural product artemisinin. Despite the development of several synthetic approaches to the natural product, a streamlined synthesis that utilizes low-cost chemical inputs ...
Chunyin Zhu, Silas P. Cook
openaire   +3 more sources

The Case for Development of 11-Aza-artemisinins for Malaria.

Current Medicinal Chemistry, 2015
The current treatment regimens for uncomplicated malaria comprise an artemisinin in combination with another drug (ACT). However, the recent emergence of resistance to ACTs in South East Asia dramatically emphasizes the need for new artemisinins.
Rozanne Harmse, H. Wong, Frans Smit, R. Haynes, D. N'Da   +4 more
semanticscholar   +1 more source

Total Synthesis and Biological Investigation of (−)‐Artemisinin: The Antimalarial Activity of Artemisinin Is not Stereospecific

Angewandte Chemie International Edition, 2018
AbstractHere, we describe an efficient and diversity‐oriented entry to both (−)‐artemisinin (1) and its natural antipode (+)‐artemisinin, starting from commercially and readily available S‐(+)‐ and R‐(−)‐citronellene, respectively. Subsequently, we answered the still open question regarding the specificity of artemisinins action.
Thomas Efferth, Marcel Kaiser, Marcel Kaiser, Athanassios Giannis, Toni Smeilus, Ean-Jeong Seo, Johannes Krieger   +6 more
openaire   +4 more sources