Results 171 to 180 of about 6,373 (213)

Artemisinins

2017
Artemisinin, also known as Qinghaosu, is the active principle extract of Qinghao (Artemisia annua L.), a plant that has been used for centuries in traditional Chinese medicine. The antimalarial properties of artemisinin were first reported in the Western literature in 1979 (Jiang et al., 1982).
Thriemer, Kamala, Simpson, Julie A., McCarthy, James S., Price, Ric N.   +3 more
exaly   +5 more sources

The birth of artemisinin

Pharmacology & Therapeutics, 2020
As the first-line antimalarial drugs, artemisinins gained wide acceptance after the emergence of resistance to chloroquine in the 1950s. Artemisinin-based drugs have saved lives, especially in developing countries. The discovery of artemisinin was unique, timely, and fascinating, and the benefits of artemisinin were with far-reaching implications ...
Nan, Ma, Ziyue, Zhang, Fulong, Liao, Tingliang, Jiang, Youyou, Tu   +4 more
openaire   +2 more sources

Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins: Relationship With Flavoenzyme Function and Antimalarial Mechanism of Action

ChemMedChem, 2010
The antimalarial drug methylene blue (MB) affects the redox behaviour of parasite flavin-dependent disulfide reductases such as glutathione reductase (GR) that control oxidative stress in the malaria parasite.
Richard K Haynes, Ian D Williams, Paolo Coghi   +2 more
exaly   +3 more sources

A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism With Chloroquine, a Reversal With Verapamil, and an Insight Into the Antimalarial Activity of Chloroquine

ChemMedChem, 2011
Artemisinins rapidly oxidize leucomethylene blue (LMB) to methylene blue (MB); they also oxidize dihydroflavins such as the reduced conjugates RFH 2 of riboflavin (RF), and FADH 2 of the cofactor flavin adenine dinucleotide (FAD), to the corresponding ...
Richard K Haynes, Paolo Coghi, Diego Monti   +2 more
exaly   +2 more sources

Artemisinins: Their Growing Importance in Medicine [PDF]

Trends in Pharmacological Sciences, 2008
Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well established for the treatment of malaria, including highly drug-resistant strains. Their efficacy also extends to phylogenetically unrelated parasitic infections such
Henry Staines, Richard K Haynes, Sanjeev Krishna   +2 more
exaly   +2 more sources

Artemisinins as a Novel Anti-Cancer Therapy: Targeting a Global Cancer Pandemic Through Drug Repurposing [PDF]

Pharmacology & Therapeutics, 2020
Artemisinins are a unique class of antimalarial drugs with significant potential for drug repurposing for a wide range of diseases including cancer. Cancer is a leading cause of death globally and the majority of cancer related deaths occur in Low and ...
Henry Staines, Yolanda Augustin, Sanjeev Krishna   +2 more
exaly   +2 more sources

The Fe2+-Mediated Decomposition, PfATP6 Binding, and Antimalarial Activities of Artemisone and Other Artemisinins: The Unlikelihood of C-Centered Radicals as Bioactive Intermediates [PDF]

ChemMedChem, 2007
The results of Fe2+-induced decomposition of the clinically used artemisinins, artemisone, other aminoartemisinins, 10-deoxoartemisinin, and the 4-fluorophenyl derivative have been compared with their antimalarial activities and their ability to inhibit ...
Donatella Taramelli, Richard K Haynes, Anne-Catrin Uhlemann   +2 more
exaly   +2 more sources

Evaluation and Optimization of Synthetic Routes From Dihydroartemisinin to the Alkylamino-Artemisinins Artemiside and Artemisone: A Test of N-Glycosylation Methodologies on a Lipophilic Peroxide

Tetrahedron, 2018
10-Alkylamino-artemisinins including artemiside and artemisone display enhanced activities against malaria. Earlier, dihydroartemisinin (DHA) TMS ether was converted by trimethylsilyl bromide into the 10-β-bromide that with amine nucleophiles provided ...
Richard K Haynes, Ho Ning Wong
exaly   +2 more sources

Interactions Between Artemisinins and Other Antimalarial Drugs in Relation to the Cofactor Model—A Unifying Proposal for Drug Action

ChemMedChem, 2012
Artemisinins are proposed to act in the malaria parasite cytosol by oxidizing dihydroflavin cofactors of redox-active flavoenzymes, and under aerobic conditions by inducing their autoxidation. Perturbation of redox homeostasis coupled with the generation
Richard K Haynes, Paolo Coghi, Kumar Sinniah   +2 more
exaly   +2 more sources

Artemisinins: Promising Drug Candidates for the Treatment of Autoimmune Diseases

Medicinal Research Reviews
Autoimmune diseases are characterized by the immune system's attack on one's own tissues which are highly diverse and diseases differ in severity, causing damage in virtually all human systems including connective tissue (e.g., rheumatoid arthritis ...
Qingwen Wang
exaly   +2 more sources