Results 211 to 220 of about 10,664,685 (382)

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

open access: yesAdvanced Science, EarlyView.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren   +11 more
wiley   +1 more source

Prevalence of Nonatheromatous Lesions in Peripheral Arterial Disease

open access: yesArteriosclerosis, Thrombosis and Vascular Biology, 2015
K. H. H. Korea   +4 more
semanticscholar   +1 more source

Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction

open access: yesAdvanced Science, EarlyView.
A microfluidic platform of engineered blood vessels is developed to study the role of mechanical forces in immune cell adhesion and extravasation in uremic microenvironments. Elevated pressure increases monocyte activity, with ICAM‐1 as a key driver. Matrix density influences monocyte phenotypes, but the uremic environment consistently promoted a pro ...
Mitesh Rathod   +9 more
wiley   +1 more source

Ventilatory Disturbance and Arterial-Alveolar N2 Differences During Recovery from Hyaline Membrane Disease [PDF]

open access: bronze, 1970
Abhijit Pathak   +4 more
openalex   +1 more source

Surgical intervention for peripheral arterial disease.

open access: yesCirculation Research, 2015
S. Vartanian, M. Conte
semanticscholar   +1 more source

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

open access: yesAdvanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni   +12 more
wiley   +1 more source

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