Results 1 to 10 of about 1,681,102 (218)

Vascular Disease, Non-Steroidal Anti-Inflammatory Drugs and Risk of Parkinson's Disease. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Wotton C, Hermon C, Floud S, Reeves G, Barnes I.   +4 more
europepmc   +2 more sources

Kallistatin limits abdominal aortic aneurysm by attenuating generation of reactive oxygen species and apoptosis

Scientific Reports, 2021
Inflammation, vascular smooth muscle cell apoptosis and oxidative stress are believed to play important roles in abdominal aortic aneurysm (AAA) pathogenesis.
Smriti Murali Krishna, Jiaze Li, Yutang Wang, Corey S. Moran, Alexandra Trollope, Pacific Huynh, Roby Jose, Erik Biros, Jianxing Ma, Jonathan Golledge   +9 more
doaj   +1 more source

Pulmonary hypertension phenotypes in patients with systemic sclerosis

European Respiratory Review, 2021
Pulmonary hypertension (PH) commonly affects patients with systemic sclerosis (SSc) and is associated with significant morbidity and increased mortality.
Ashraful Haque, David G. Kiely, Gabor Kovacs, A.A. Roger Thompson, Robin Condliffe   +4 more
doaj   +1 more source

Elective lower limb orthopedic arthroplasty surgery in patients with pulmonary hypertension

Pulmonary Circulation, 2022
Patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (PH) are at increased risk when undergoing anesthesia and major surgery. Data on outcomes for elective orthopedic surgery in patients with PH are limited.
Mikaela Wardle, Amanda Nair, Sarah Saunders, Iain Armstrong, Athanasios Charalampopoulos, Charlie Elliot, Abdul Hameed, Neil Hamilton, John Harrington, Carol Keen, Robert Lewis, Ian Sabroe, A. A. Roger Thompson, Robert M. Kerry, Robin Condliffe, David G. Kiely   +15 more
doaj   +1 more source

Short endovenous laser ablation of the great saphenous vein in a modified CHIVA strategy

Veins and Lymphatics, 2013
Mini-invasiveness, ease of use and execution speed represent the reasons for endovenous laser ablation success. Nevertheless, the strategic choice remains the ablation of the saphenous trunk.
Sergio Gianesini, Erica Menegatti, Michele Zuolo, Mirko Tessari, Simona Ascanelli, Savino Occhionorelli, Paolo Zamboni   +6 more
doaj   +1 more source

Aortic Geometric Alteration Associated With Acute Type B Aortic Dissection: Angulation, Tortuosity, and Arch Type

Frontiers in Physiology, 2021
Background: Acute type B aortic dissection is a highly serious aortic pathology. Aortic geometric parameters may be useful variables related to the occurrence of acute type B aortic dissection (aTBAD).
Likun Sun, Likun Sun, Jiehua Li, Jiehua Li, Lunchang Wang, Lunchang Wang, Quanming Li, Quanming Li, Hao He, Hao He, Xin Li, Xin Li, Ming Li, Ming Li, Tun Wang, Tun Wang, Chenglei Zhao, Chenglei Zhao, Xiaolong Zhang, Xiaolong Zhang, Chang Shu, Chang Shu, Chang Shu   +22 more
doaj   +1 more source

Spontaneous thrombosis of primary external jugular veins aneurysms

Veins and Lymphatics, 2013
External jugular vein (EJV) aneurysms represent a rare condition whose origin, evolution and consequent best therapeutic options still need further investigations. We present herein two peculiar clinical cases. In the first one, an EJV aneurysm developed
Sergio Gianesini, Erica Menegatti, Michele Zuolo, Savino Occhionorelli, Simona Ascanelli, Paolo Zamboni   +5 more
doaj   +1 more source

BNP/NT-proBNP in pulmonary arterial hypertension: time for point-of-care testing?

European Respiratory Review, 2020
Despite the advent of new therapies and improved outcomes in patients with pulmonary arterial hypertension (PAH), it remains a life-shortening disease and the time to diagnosis remains unchanged.
Robert A. Lewis, Charlotte Durrington, Robin Condliffe, David G. Kiely   +3 more
doaj   +1 more source

NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension

Signal Transduction and Targeted Therapy, 2023
Hypertension is characterized by endothelial dysfunction and arterial stiffness, which contribute to the pathogenesis of atherosclerotic cardiovascular diseases.
Yumin Qiu, Shiyue Xu, Xi Chen, Xing Wu, Zhe Zhou, Jianning Zhang, Qiang Tu, Bing Dong, Zhefu Liu, Jiang He, Xiaoyu Zhang, Shuangshuang Liu, Chen Su, Hui Huang, Wenhao Xia, Jun Tao   +15 more
doaj   +1 more source

Protein engineering to develop a redox insensitive endothelial nitric oxide synthase

Redox Biology, 2014
The zinc tetrathiolate (ZnS4) cluster is an important structural feature of endothelial nitric oxide synthase (eNOS). The cluster is located on the dimeric interface and four cysteine residues (C94 and C99 from two adjacent subunits) form a cluster with ...
Ruslan Rafikov, Sanjiv Kumar, Saurabh Aggarwal, Daniel Pardo, Fabio V. Fonseca, Jessica Ransom, Olga Rafikova, Qiumei Chen, Matthew L. Springer, Stephen M. Black   +9 more
doaj   +1 more source