Results 1 to 10 of about 667,198 (303)

Early treatment with ambrisentan of mildly elevated mean pulmonary arterial pressure associated with systemic sclerosis: a randomized, controlled, double-blind, parallel group study (EDITA study)

Arthritis Research & Therapy, 2019
Objective The objective of this randomized, placebo-controlled, double-blind, parallel group, trial was to assess the effect of ambrisentan on mean pulmonary arterial pressure (mPAP) in patients with systemic sclerosis (SSc) and mildly elevated pulmonary
Zixuan Pan, Alberto M. Marra, Nicola Benjamin, Christina A. Eichstaedt, Norbert Blank, Eduardo Bossone, Antonio Cittadini, Gerry Coghlan, Christopher P. Denton, Oliver Distler, Benjamin Egenlauf, Christine Fischer, Satenik Harutyunova, Panagiota Xanthouli, Hanns-Martin Lorenz, Ekkehard Grünig   +15 more
doaj   +1 more source

Under pressure: pulmonary hypertension associated with left heart disease. [PDF]

, 2015
© ERS 2015.Pulmonary hypertension (PH) associated with left heart disease (PH-LHD) is the most common type of PH, but its natural history is not well understood.
Farber, HW, Gibbs, S
core   +2 more sources

Dobutamine stress MRI in pulmonary hypertension: relationships between stress pulmonary artery relative area change, RV performance, and 10-year survival [PDF]

, 2017
In pulmonary hypertension (PH), right ventricular (RV) performance determines survival. Pulmonary artery (PA) stiffening is an important biomechanical event in PH and also predicts survival based on the PA relative area change (RAC) measured at rest ...
Bellofiore, Alessandro, Blyth, Kevin G., Chesler, Naomi C., Foster, John E., Jayasekera, Geeshath, Peacock, Andrew J., Steedman, Tracey   +6 more
core   +1 more source

Long-term oxygen therapy in precapillary pulmonary hypertension – SOPHA study

Scientific Reports
Current guidelines recommend oxygen (O2) supplementation in patients with pulmonary hypertension (PH), despite scarce data on long-term O2 therapy (LTOT).
Nicola Benjamin, Ishan Echampati, Satenik Harutyunova, Christina Alessandra Eichstaedt, Benjamin Egenlauf, Silvia Ulrich, Ekkehard Grünig, Panagiota Xanthouli   +7 more
doaj   +1 more source

Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity [PDF]

, 2014
Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator ...
Baust, Jeff, Bonacci, Gustavo Roberto, Cantu Medellin, Nadiezhda, Champion, Hunter C., Croix, Claudette M. St., Devlin, Jason E., Freeman, Bruce A., Frisbee,Jefferson C., Gladwin, Mark T., Golin Bisello, Franca, Gor, Sonia, Kelley, Eric E., Khoo, Nicholas K.H., Watkins, Simon C., Weidert, Eric R.   +14 more
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MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase [PDF]

, 2019
Nicotinamide phosphoribosyltransferase (NAMPT) upregulation in human pulmonary artery endothelial cells (hPAECs) is associated with pulmonary arterial hypertension (PAH) progression and pulmonary vascular remodeling.
Chen, Jiwang, Chen, Tianji, Dong, Yangbasai, Gao, Hui, Machado, Roberto F., Song, Yang, Wang, Yifang, Zhao, Shuangping   +7 more
core   +1 more source

Endothelin-1 Predicts Hemodynamically Assessed Pulmonary Arterial Hypertension in HIV Infection. [PDF]

, 2016
BackgroundHIV infection is an independent risk factor for PAH, but the underlying pathogenesis remains unclear. ET-1 is a robust vasoconstrictor and key mediator of pulmonary vascular homeostasis.
AH Chester, Amanda S. Heringer, B Degano, B Degano, BJ Kircher, C Rubens, D Iglesias, D Shao, DB Badesch, F Bohm, F Leyva, G Barbaro, G Zou, GD Kanmogne, H Ehrenreich, H Nunes, James West, JD Rich, Jeffrey N. Martin, John S. Macgregor, LJ Rubin, M Berger, M Nootens, M Opravil, M Opravil, M Yoshibayashi, MQ Feijoo, MR Fisher, MT Gladwin, N Galie, N Galie, O Sitbon, O Sitbon, Peter Ganz, Priscilla Y. Hsue, PY Hsue, R Tibshirani, Rebecca Scherzer, RJ Oudiz, RN Channick, RN Channick, Rushi V. Parikh, RV Parikh, RV Parikh, S Almodovar, S Almodovar, S Shapiro, Steven G. Deeks, T Thenappan, VN Selby, VV McLaughlin, Yifei Ma   +51 more
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Right Heart Size and Right Ventricular Reserve in Pulmonary Hypertension: Impact on Management and Prognosis

Diagnostics, 2020
Various parameters reflecting right heart size, right ventricular function and capacitance have been shown to be prognostically important in patients with pulmonary hypertension (PH).
Ekkehard Grünig, Christina A. Eichstaedt, Rebekka Seeger, Nicola Benjamin   +3 more
doaj   +1 more source

Cardiac sympathetic dysfunction in pulmonary arterial hypertension: Lesson from left-sided heart failure [PDF]

, 2019
Sympathetic nervous system hyperactivity has a well-recognized role in the pathophysiology of heart failure with reduced left ventricular ejection fraction.
Bonaduce, Domenico, Bosso, Giorgio, Campi, Giacomo, Cuocolo, Alberto, Hassoun, Paul, Mercurio, Valentina, Parrella, Paolo, Pellegrino, Teresa, Petretta, Mario, Piscopo, Valentina, Tocchetti, Carlo Gabriele   +10 more
core   +1 more source

Compensated right ventricular function of the onset of pulmonary hypertension in a rat model depends on chamber remodeling and contractile augmentation. [PDF]

, 2018
Right-ventricular function is a good indicator of pulmonary arterial hypertension (PAH) prognosis; however, how the right ventricle (RV) adapts to the pressure overload is not well understood.
Abe K, Alencar A, Arts T, Bellofiore A, Benoist D, Benoist D, Blaudszun G, Cheng DC, Correia-Pinto J, de Man FS, Ewalenko P, Gomez-Arroyo JG, Guccione JM, Handoko ML, Handoko ML, Hardy MEL, Hessel MHM, Hoeper MM, Langer SFJ, Lee LC, Pacher P, Provencher S, Rain S, Schermuly RT, Shintani H, ter Keurs HE, Trip P, Umar S, Vaillancourt M, Vanderpool RR, Vinnakota KC, Wang Z, Werchan PM, White RJ, Yin X, Zhang X   +35 more
core   +1 more source