Results 291 to 300 of about 10,664,685 (382)

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Perirenal adipose tissue accumulation mediates the adverse impact of the atherogenic index of plasma on lower extremity peripheral arterial disease. [PDF]

Sci Rep
Guo XL, Tu M, Qiu XP, Wang W.
europepmc   +1 more source

III-5 Experience of omental transplantation in the re-operation of the chronic arterial occlusive diseases

, 1977
星野 俊一, 猪狩 次雄, 鈴木 湧, 板橋 邦宏, 高野 光太郎, 阿部 俊文, 安藤 正樹, Sophie Hamada, 鈴木 俊雄, 本多 憲児   +9 more
openalex   +2 more sources

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

Validation of High Ischemic and Bleeding Risk Criteria of European Guidelines in Peripheral Arterial Disease. [PDF]

JACC Asia
Yamamoto K, Saito Y, Ohno Y, Oka N, Takahara M, Suzuki S, Uchiyama R, Suzuki M, Matsumoto T, Iwata Y, Kobayashi Y.   +10 more
europepmc   +1 more source

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

Advanced Science, EarlyView.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang, Peixin Liu, Wenru Shen, Chao Li, Zhenhao Zhao, Yuxing Wu, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Impact of a Nurse-Led Lifestyle Intervention on Functional Capacity and Quality of Life in Peripheral Arterial Disease: A Controlled Study.

J Pharm Bioallied Sci
Santhipriya A, Selvanayaki V.
europepmc   +1 more source

Sauna use as a novel management approach for cardiovascular health and peripheral arterial disease. [PDF]

Front Cardiovasc Med
Sastriques-Dunlop S, Elizondo-Benedetto S, Zayed MA.   +2 more
europepmc   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source