Results 291 to 300 of about 10,598,225 (397)

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

Advanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang   +9 more
wiley   +1 more source

Segmental Pulse Volume Recordings at the Forefoot Level as a Valuable Diagnostic Tool for Detection of Peripheral Arterial Disease in the Diabetic Foot Syndrome. [PDF]

Biomedicines
Nützel A, Reik LJU, Hamberger M, Lottspeich C, Deniz S, Löw A, Schneider H, Polzer H, Baumbach S, Czihal M.   +9 more
europepmc   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source

Intravascular Shockwave Lithotripsy for the Treatment of Severe Peripheral Arterial Disease: A Single-Centre Experience. [PDF]

Cureus
Salihi S, Suleiman O, Afzal Tarar B, Yaldo F, Najem M.   +4 more
europepmc   +1 more source

The prevalence of peripheral arterial disease in a defined population.

, 1985
Michael H. Criqui, A Fronĕk, Elizabeth Barrett‐Connor, Melville R. Klauber, S Gabriel, David C. Goodman   +5 more
openalex   +1 more source

Ferrocene‐Functionalized Black Phosphorus Nanoplatform Enables Targeted and Prolonged MRI Visualization of Atherosclerotic Plaques

Advanced Science, EarlyView.
Aminoferrocene is employed to modify black phosphorus, generating stable phosphorus radicals (FcP). The FcP is then functionalized with hyaluronic acid (HA) to produce the HA‐FcP radical complex, thereby developing a novel, highly efficient, sensitive, long‐lasting, and low‐heavy‐metal‐content radical contrast agent for targeted imaging of ...
Xiao Huang, Yuanyuan Zhao, Miao Zhou, Yukang Guo, Haiyun Wang, Yuanyuan Chen, Jian Peng   +6 more
wiley   +1 more source

Atherectomy in the Treatment of Peripheral Arterial Disease-A Case Series to Demonstrate Preferable Indications with Good Outcomes and a Literature Review. [PDF]

J Clin Med
Lizwan M, Yap HY, Ch'ng JK, Chong TT, Ng NZP.   +4 more
europepmc   +1 more source

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

Advanced Science, EarlyView.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang, Peixin Liu, Wenru Shen, Chao Li, Zhenhao Zhao, Yuxing Wu, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Clinical and disease characteristics from REVEAL at time of enrollment (baseline): Prospective observational study of patients with polycythemia vera in the United States [PDF]

, 2018
Boccia, Ralph V, Colucci, Philomena, Grunwald, Michael R, Mesa, Ruben, Oh, Stephen T, Paranagama, Dilan, Parasuraman, Shreekant, Stein, Brady L   +7 more
core   +1 more source