Results 41 to 50 of about 721,295 (295)

Why some treated patients with arterial hypertension do not report of having it: Findings from epidemiological studies

Arterial Hypertension, 2023
BACKGROUND: Diagnosis of hypertension (HT) in epidemiological studies sometimes requires careful clinical evaluation. This may be particularly challenging in the subgroup of patients taking antihypertensive drugs for indications other than HT.
Piotr S. Szczęsny, Kacper Jagiełło, Krzysztof Flis, Tomasz Zdrojewski   +3 more
doaj   +1 more source

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. [PDF]

, 2018
Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension ...
Ayon, Ramon J, Balistrieri, Angela, Black, Stephen M, Chen, Jiwang, Desai, Ankit A, Garcia, Joe GN, Gu, Yali, Makino, Ayako, Rischard, Franz, Song, Shanshan, Tang, Haiyang, Vanderpool, Rebecca, Vinjamuri, Sujana, Wang, Jian, Wang, Ziyi, Wu, Kang, Yuan, Jason X-J, Zhang, Qian, Zhou, Guofei   +18 more
core   +1 more source

Amiloride reduces portal hypertension in rat liver cirrhosis [PDF]

, 2010
Objective This study aimed to investigate the effect of amiloride on portal hypertension. Amiloride is known to inhibit Na(+)/H(+) exchangers on activated hepatic stellate cells.
Beitinger, Frigga, Bystron, Markus, De Toni, Enrico N., Gerbes, Alexander L., Hartmann, Anna C., Hennenberg, Martin, Steib, Christian J.   +6 more
core   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Sex and other predictors of mortality in long-term follow-up of patients with cardiovascular disease and COVID-19: a single-center retrospective study

Scientific Reports
Male sex is a well-known predictor of short-term prognosis in patients with coronavirus disease (COVID-19). Data, however, on long-term outcomes are scarce. We aimed to assess the differences in mortality between sexes and find other important predictors
Maryla Kocowska-Trytko, Michał Terlecki, Agnieszka Olszanecka, Christopher Pavlinec, Marek Rajzer, CraCov HHS Investigators   +5 more
doaj   +1 more source

The evolutionary development of the renin angiotensin aldosterone system and its importance for the survival of the human species

Arterial Hypertension, 2021
Kidneys produce a number of substances that affect intrarenal blood circulation; however, the key system that regulates blood flow in both general and local circulation (including the renal circulation) is the renin-angiotensinaldosterone system (RAAS ...
Natalia Butt-Hussaim, Jacek Manitius
doaj   +1 more source

Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment. [PDF]

, 2020
Altered metabolism in pulmonary artery smooth muscle cells (PASMCs) and endothelial cells (PAECs) contributes to the pathology of pulmonary hypertension (PH), but changes in substrate uptake and how substrates are utilized have not been fully ...
D' Alessandro, Angelo, Freeman, Scott, Graham, Brian B, Gu, Sue, Hernandez-Saavedra, Daniel, Kassa, Biruk, Kumar, Rahul, Lee, Michael H, Mickael, Claudia, Reisz, Julie A, Sanders, Linda, Stenmark, Kurt R, Tuder, Rubin M   +12 more
core   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

A nonspecific clinical picture and the course of Conn syndrome — current findings in the screening program for hypertensive patients

Arterial Hypertension, 2023
Conn syndrome (CS), next to bilateral adrenal hyperplasia, is one of the most common causes of primary hyperaldosteronism. It leads to potentially curable secondary hypertension.
Jakub Orczyk, Aleksandra Ołownia, Jakub Krzysztof Gałązka, Agnieszka Polak, Beata Matyjaszek-Matuszek   +4 more
doaj   +1 more source

Micro-CT Image-Derived Metrics Quantify Arterial Wall Distensibility Reduction in a Rat Model of Pulmonary Hypertension [PDF]

, 2000
We developed methods to quantify arterial structural and mechanical properties in excised rat lungs and applied them to investigate the distensibility decrease accompanying chronic hypoxia-induced pulmonary hypertension. Lungs of control and hypertensive
Dawson, Christopher A, Haworth, Steven Thomas, Johnson, Roger H., Karau, Kelly L., Molthen, Robert C.   +4 more
core   +1 more source