Results 181 to 190 of about 13,431 (262)

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12 ‐Related Developmental Disorders

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1619-1650, July 2026.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken   +4 more
wiley   +1 more source

A phase‐II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment

open access: yesAlzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Declining nicotinamide adenine dinucleotide (NAD+) may elevate risk of Alzheimer's disease. METHODS We conducted a 12‐week double‐blind, randomized, placebo‐controlled pilot study to evaluate the safety, tolerability, and preliminary efficacy of the NAD+ precursor, nicotinamide riboside (NR), for enhancing cognitive function and ...
Christopher R. Martens   +16 more
wiley   +1 more source

Lysyl Oxidase Reduces Neutrophil Extravasation in Response to P. aeruginosa in an Infection‐on‐a‐Chip Model

open access: yesAdvanced NanoBiomed Research, Volume 6, Issue 7, July 2026.
Lysyl oxidase crosslinking of type I collagen decreases neutrophil extravasation through an endothelium during the initial response to P. aeruginosa. This decrease in extravasation is likely due to the increase in VE‐cadherin expression between endothelial cells seeded on LOX‐crosslinked collagen hydrogels.
Christopher J. Calo   +7 more
wiley   +1 more source

Stroke‐Mimic: An Intracranial Dural Arteriovenous Fistula Revealed by New‐Onset Seizures and Post‐Ictal Deficit

open access: yesClinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Intracranial dural arteriovenous fistulas (iDAVFs) are rare vascular malformations with diverse neurological symptoms depending on their venous drainage pattern. We describe a 59‐year‐old man who presented with transient right‐sided weakness and facial droop following new‐onset seizures. CT demonstrated asymmetric arterial‐phase enhancement of
Michael Van Haute   +2 more
wiley   +1 more source

Betulinaldehyde Ameliorates Aβ‐Induced Neurotoxicity and Cognitive Deficits by Modulating the eEF2K/eEF2 Pathway

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Betulinaldehyde exerts protective effects against Aβ42‐induced neuronal damage by modulating the eEF2K/eEF2 pathway to restore protein synthesis and reduce oxidative stress. In Aβ42‐induced mouse model, betulinaldehyde treatment alleviates hippocampal pathology and cognitive deficits, highlighting it as a potential candidate agent for AD treatment ...
Chaoqun Wang   +15 more
wiley   +1 more source

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