Results 191 to 200 of about 13,431 (262)

Precision medicine for atherosclerotic cardiovascular disease: Integrative genomics maps risk loci and AI‐predicted functional consequences

open access: yesClinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Genomic SEM of five ASCVD traits in > 3.8 million individuals identified 347 risk variants, including 19 novel loci. Integrating fine‐mapping and TWAS prioritized causal genes and revealed endothelial cell enrichment in vascular tissues. AI modelling shows the DCLRE1B mutation destabilizes the protein, impairing DNA repair and transcription.
Liwan Fu   +4 more
wiley   +1 more source

Arterial spin labeling MRI in assessing cerebral blood flow changes due to hypertension: a systematic review. [PDF]

open access: yesJ Hypertens
Muthu SS   +12 more
europepmc   +1 more source

Luteolin Glycoside From Dracocephalum moldavica L. Attenuates COPD by Modulating TLR4 Expression and Alveolar Cross‐Talk

open access: yesFood Frontiers, Volume 7, Issue 4, July 2026.
Luteolin‐7‐O‐β‐d‐glucuronide mitigates CS‐induced COPD progression by promoting cytokine‐mediated functional cross‐talk between alveolar macrophages and epithelial cells. ABSTRACT Chronic obstructive pulmonary disease (COPD) is associated with inflammation of the airway and lung parenchyma with limited airflow due to continued exposure to harmful ...
Jianhu Jia   +13 more
wiley   +1 more source

Diurnal Variations and Test–Retest Reliability of Resting‐State Functional MRI Metrics

open access: yesHuman Brain Mapping, Volume 47, Issue 10, July 2026.
Regional homogeneity (ReHo) exhibited the highest within‐day reliability, whereas fractional amplitude of low‐frequency fluctuations (fALFF) showed the lowest. The limbic network demonstrated the lowest reliability among the networks, with a notable mid‐morning dip at 10:00. ABSTRACT Resting‐state fMRI (rs‐fMRI) is widely used to assess intrinsic brain
Bowen Guo   +12 more
wiley   +1 more source

Prognostic value of arterial spin-labeling perfusion in anoxic brain injury: A retrospective cohort study. [PDF]

open access: yesWorld J Radiol
Beutler BD   +9 more
europepmc   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

open access: yesInterdisciplinary Medicine, Volume 4, Issue 4, July 2026.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li   +24 more
wiley   +1 more source

S100A9 Aggravates Cardiac Fibrosis by TLR4/PGC‐1α Mediated Macrophage‐Myofibroblast Crosstalk

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
ABSTRACT Fibrosis is a critical component of ventricular remodelling after myocardial ischemia, and the activation and expansion of cardiac fibroblasts represent key drivers of this process. Our previous work identified S100A9‐dependent macrophage‐to‐myofibroblast transition (MMT) as a newly recognized source of myofibroblasts in the post‐MIR heart ...
Yiting Zhao   +6 more
wiley   +1 more source

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