Results 31 to 40 of about 530 (214)

A successful management of late-presenting transposition with intact septum and severe coarctation of the aorta

open access: yesSAGE Open Medical Case Reports, 2020
A 13-week-old baby was referred with dextrocardia, situs inversus, transposition of the great arteries, intact ventricular septum, patent foramen ovale , right aortic arch with severe preductal aortic coarctation and large patent ductus arteriosus.
Pribadi Wiranda Busro   +2 more
doaj   +1 more source

Ductal recanalization and stenting for late presenters with TGA intact ventricular septum

open access: yesAnnals of Pediatric Cardiology, 2011
Introduction: The ideal management strategy for patients presenting late with transposition of great arteries (TGA), intact ventricular septum (IVS), and regressed left ventricle (LV) is not clear.
Shyam S Kothari   +4 more
doaj   +1 more source

D-Transposition of the Great Arteries: A New Era in Cardiology

open access: yesCardiovascular Innovations and Applications, 2018
Before the 1950s, D-transposition of the great arteries was associated with nearly 90% mortality within the first year of life. The Mustard and Senning procedures resulted in a significant increase in the lifespan of these patients but with notable long ...
Angeline D. Opina, Wayne J. Franklin
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

D-Transposition of great arteries with severe calcific aortic stenosis in an adult patient: a rare presentation

open access: yesPolish Journal of Thoracic and Cardiovascular Surgery, 2022
The incidence of transposition of great arteries (TGA) is 31 per 100000 live births worldwide [1]. It is, however, the most common cyanotic congenital heart defect seen in neonates [2].
Prashant Mishra   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Neoaortic Bicuspid Valve Replacement in Patient After Arterial Switch Operation to Correct Dextro-Transposition of the Great Arteries

open access: yesНеотложная медицинская помощь, 2023
INTRODUCTION Transposition of the great arteries is the second most common cyanotic congenital heart defect after tetralogy of Fallot. The arterial switch procedure (А. Jatene, 1975) is the surgical treatment of choice.
V. S. Selyaev   +6 more
doaj   +1 more source

Coronary Arteries After Arterial Switch Surgery

open access: yesJournal of the American College of Cardiology, 2006
I read with special interest the recent study by Pedra et al. ([1][1]) on intravascular ultrasound (IVUS) imaging of the coronary arteries after switch operation for transposition of the great arteries.
openaire   +2 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina   +11 more
wiley   +1 more source

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