Results 71 to 80 of about 42,170 (187)

The Use of Hexamethonium in Treatment of Arteriosclerosis Obliterans [PDF]

Circulation, 1955
The effect of hexamethonium on hypertension has been widely studied but its effect on the peripheral blood vessels of patients with severe occlusive vascular disease has been studied on only a few patients although the drug has been used empirically in the treatment of such disease.
J H, WINDESHEIM, G M, ROTH, R W, GIFFORD
openaire   +2 more sources

A Phenomenological Study of Older Individuals' Experiences of Safety at Home

Scandinavian Journal of Caring Sciences, Volume 39, Issue 4, December 2025.
ABSTRACT Aims and Objectives To identify the elements of safety for older individuals living at home and how they describe safety as a lived experience. Methodological Design and Justification The research design was based on a phenomenological inquiry. The narratives were older individuals' own experiences of safety at home.
Kivimäki Taina, Stolt Minna, Charalambous Andreas, Katajisto Jouko, Suhonen Riitta   +4 more
wiley   +1 more source

Impact of Heart Failure and Chronic Kidney Disease on All‐Cause Mortality in Patients Undergoing Coronary Angiography: Results From the Finnish Kardio Multicentre Registry

Catheterization and Cardiovascular Interventions, Volume 106, Issue 4, Page 2351-2360, October 1, 2025.
ABSTRACT Background Heart failure (HF) and chronic kidney disease (CKD) are common comorbidities among patients undergoing coronary angiography. Both conditions are associated with increased risk of adverse cardiovascular outcomes and mortality. However, the joint prognostic impact of HF and CKD in this patient population remains unclear. Aims We aimed
Jari A. Laukkanen, Jaakko Immonen, Jussi Hernesniemi, Mari Merentie, Ashish H. Shah, Markku Eskola, Sudhir Kurl, Setor K. Kunutsor   +7 more
wiley   +1 more source

Ferritinophagy Is Involved in the Advanced Glycation End Products‐Induced Ferroptosis of Vascular Endothelial Cells in Diabetes Mellitus

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT This study investigated the role of advanced glycation end products (AGEs) and ferritinophagy‐dependent ferroptosis in the pathogenesis of diabetic atherosclerosis obliterans. We investigated the effects of AGEs on ferroptosis and ferritinophagy in HUVECs.
Yi Huang, Yongzhi Jin, Junsheng Hu, Mengfan Li, Ming Tian, Guang Zeng, Rong Huang   +6 more
wiley   +1 more source

Association of red blood cell distribution width/albumin ratio with renal prognosis among patients with type 2 diabetes mellitus: A retrospective cohort study

Journal of Diabetes Investigation, Volume 16, Issue 10, Page 1829-1835, October 2025.
Red cell distribution width (RDW)/serum albumin ratio (RAR) is a novel and simple inflammatory marker and has emerged as a reliable prognostic marker in various diseases. Our study reveals that a high RAR is a practical and easily obtainable predictive tool for assessing renal risk in patients with T2DM, thereby offering a tangible benefit to ...
Hiroshi Kimura, Kenichi Tanaka, Hirotaka Saito, Sakumi Kazama, Michio Shimabukuro, Koichi Asahi, Tsuyoshi Watanabe, Junichiro James Kazama   +7 more
wiley   +1 more source

Effects of sarpogrelate, eicosapentaenoic acid and pitavastatin on arterioslcerosis obliterans-related biomarkers in patients with type 2 diabetes (SAREPITASO study)

Vascular Health and Risk Management, 2018
Shosaku Nomura,1 Takehito Taniura,2 Akira Shouzu,3 Seitaro Omoto,4 Masahiko Suzuki,5 Yoshinori Okuda,6 Tomoki Ito1 1First Department of Internal Medicine, Kansai Medical University, Hirakata, 2Division of Internal Medicine, Daiwa Hospital, Suita ...
Nomura S, Taniura T, Shouzu A, Omoto S, Suzuki M, Okuda Y, Ito T   +6 more
doaj  

Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Predict Severity and Prognosis of Lower Limb Arteriosclerosis Obliterans

Annals of Vascular Surgery, 2020
Background The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are 2 markers of inflammation, which are associated with worse cardiovascular disease outcomes.
M. Ye, Xin Qian, Xiangjiang Guo, Han Wang, Q. Ni, Yiping Zhao, G. Xue, Hao-yu Deng, Lan Zhang   +8 more
semanticscholar   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, Volume 24, Issue 8, August 2025.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source

The role of miR‐4284 in cancer progression and therapeutic response: Regulatory mechanisms and clinical implications

Malignancy Spectrum, Volume 2, Issue 2, Page 59-73, June 2025.
As a pivotal microRNA (miRNA), miR‐4284 exhibits noteworthy aberrant expression levels across various cancers and diseases, exerting a crucial role in modulating cancer progression and prognosis. Additionally, the article reviews the potential correlations between miR‐4284 and various contemporary treatment modalities, including but not limited to the ...
Chenhao Liang, Yaojie Feng, Yuhua Zhang, Zehua Wang, Xinming Su, Shiwei Duan   +5 more
wiley   +1 more source

Japan's Conditional/Time‐Limited Early Approval System in Regenerative Medicine: A Case Study of Rise and Falls of Autologous Skeletal Myoblast Sheets

Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1171-1174, May 2025.
Japan's conditional/time‐limited early approval program, initiated in 2014, aimed to advance regenerative medicine by expediting market access. However, the withdrawal of autologous skeletal myoblast sheets (Heartsheet) due to ineffectiveness raises concerns about the balance between rapid approval and scientific integrity.
Hayase Hakariya, Akihiko Ozaki, Yudai Kaneda, Tetsuya Tanimoto   +3 more
wiley   +1 more source