Results 31 to 40 of about 228,975 (261)

Pathogenesis and modern methods for treatment of hip infectious arthritis: a review [PDF]

Travmatologiâ i Ortopediâ Rossii
Background. One of the little-studied but long-known problems is determining the optimal treatment regimen for patients with infectious arthritis of the hip joint.
Denis I. Astakhov, Vasily A. Artyukh
doaj   +1 more source

Efficacy and safety of upadacitinib in patients with ankylosing spondylitis refractory to biologic therapy: 1-year results from the open-label extension of a phase III study

Arthritis Research & Therapy, 2023
Background Upadacitinib, a Janus kinase inhibitor, has demonstrated efficacy and an acceptable safety profile in patients with ankylosing spondylitis (AS) in the phase III SELECT-AXIS programs. We report the 1-year efficacy and safety in patients with AS
Xenofon Baraliakos, Désirée van der Heijde, Joachim Sieper, Robert D. Inman, Hideto Kameda, Yihan Li, Xianwei Bu, Anna Shmagel, Peter Wung, In-Ho Song, Atul Deodhar   +10 more
doaj   +1 more source

Skeletal pathology and variable anatomy in elephant feet assessed using computed tomography [PDF]

, 2017
Foot problems are a major cause of morbidity and mortality in elephants, but are underreported due to difficulties in diagnosis, particularly of conditions affecting the bones and internal structures. Here we evaluate post-mortem computer tomographic (CT)
Benjamin, Carciofi, Carlson, Choudhury, Craig, Csuti, Dyson, Dyson, Fowler, Fowler, Gage, Galateanu, Genin, Hagihara, Haspeslagh, Hautier, Hittmair, Hutchinson, Hutchinson, Kaulfers, Kofler, Lewis, Luikart, Miller, Morandi, Muehleman, Mumby, Nigam, O’Brien, O’Donnell, Panagiotopoulou, Pritchett, Ramsay, Regnault, Roth, Ruhoy, Sarin, Shaibani, Siegal-Willott, Siegal-Willott, Steel, Stilson, Weissengruber   +42 more
core   +5 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern. The fragile balance between infections and autoimmunity [PDF]

, 2020
On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency.
Diamanti, A. P., Lagana, B., Pioli, C., Rosado, M. M., Sesti, G.   +4 more
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Cytomegalovirus is associated with depression and anxiety in older adults [PDF]

, 2008
Infection with cytomegalovirus (CMV), a β-herpesvirus, is common within the population. Although asymptomatic, infection is associated with increased serum concentrations of cytokines such as TNFα and IL-6, which are also related to mood and wellbeing ...
Akbar, Almanzar, Anisman, Anna C. Phillips, Dantzer, Douglas Carroll, Forsey, Franceschi, Glaser, Goldberg, Irwin, Kelley, Khan, Licastro, Maes, Mehta, Miller, Miller, Musiani, Naeem Khan, Nieto, Olsson, Paul Moss, Pawelec, Phillips, Rasmussen, Reichenberg, Stinski, Stowe, Tiemeier, Torfason, Trzonkowski, Trzonkowski, van Zanten, Vollmer-Conna, Wright   +35 more
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Bacteriological and Histopathological Evaluation of Articulations of Chickens Diagnosed with Arthritis

Brazilian Journal of Poultry Science
ABSTRAT Arthritis implies inflammation of the intra-articular structures and is one of the causes of condemnation in broilers. The disease is associated with infectious agents such as Staphylococcus aureus, which may pose a potential public health risk ...
AV Marcon, GF De Oliveira, FR Caldara, RG Garcia, RA Matins, A Marcon, C Crone, ASA Assunción   +7 more
doaj   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source