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Aspirin in Juvenile Rheumatoid Arthritis
Archives of Pediatrics & Adolescent Medicine, 1985How does the rheumatologist respond to the report by Remington et al 1 of three patients with Reye syndrome who were treated with aspirin for juvenile rheumatoid arthritis? It is not an easy matter. Although juvenile rheumatoid arthritis is an infrequent disease and Reye syndrome is an unusual complication of salicylate therapy and viral disease, it ...
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The Immunogenetics of Juvenile Rheumatoid Arthritis
Rheumatic Disease Clinics of North America, 1991Recent major advances in understanding the genetic structure of the human leukocyte antigen (HLA) region and how HLA molecules contribute to immune responses have been paralleled by more precise identification of specific HLA genes conferring susceptibility to the various forms of juvenile rheumatoid arthritis (JRA).
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Treatment of juvenile rheumatoid arthritis
Current Opinion in Rheumatology, 1993New information on the treatment of juvenile rheumatoid arthritis emphasizes more aggressive control of arthritis, particularly the use of methotrexate, both in low- and higher-dose regimens. Information concerning drug toxicity, including that of the nonsteroidal anti-inflammatory drugs, second-line agents, and methotrexate, suggests that these drugs ...
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Juvenile rheumatoid arthritis and spondyloarthropathies
Current Opinion in Rheumatology, 1995Further insight into the etiology and pathogenesis of juvenile rheumatoid arthritis (JRA) is presented in recent immunogenetic studies, particularly the allele associations of the pauciarticular pattern of disease. Evidence suggests that bacterial heat-shock proteins may be significant in the chronic inflammatory response in children with arthritis ...
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Juvenile Rheumatoid Arthritis of the Foot
Foot & Ankle, 1982Rheumatoid arthritis occurring in children under 16 years of age is defined as juvenile rheumatoid arthritis. It is more common in females and the peak incidence is between 1 and 3 years of age. It can present in different forms. Mono- and pauciarticular type is complicated by iridocyclitis in 20%. Growth disturbances are common.
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Immunopathogenesis of juvenile rheumatoid arthritis
Current Opinion in Rheumatology, 1999The immunopathogenic mechanisms of juvenile rheumatoid arthritis (JRA) have been debated. A possible cellular-mediated hypothesis versus a possible B cell hyperreactivity have been entertained. This review will focus on some recent cellular work in JRA and also further evaluation of cytokine levels and their role in inflammation in JRA.
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