Results 61 to 70 of about 296,448 (281)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

AGE-DEPENDENT INDEXES OF IMMUNITY IN THE PATIENTS WITH PSORIATIC ARTHRITIS

Медицинская иммунология, 2019
Psoriatic arthritis is a chronic progressive systemic inflammatory disease of joints and spine, which leads to the development of erosive arthritis, bone resorbtion, multiple enthesitis and spondylitis. Severe clinical course, resistance to therapy, high
A. A. Barilo, S. V. Smirnova, M. V. Smolnikova   +2 more
doaj   +1 more source

Linking the effect of psoriatic arthritis-related foot involvement to the Leeds Foot Impact Scale using the International Classification for Functioning, Disability and Health: a study to assess content validity

Journal of Foot and Ankle Research, 2020
Background Previous research to describe the impact of foot involvement in psoriatic arthritis has used the Leeds Foot Impact Scale in Rheumatoid Arthritis (LFIS-RA) in the current absence of any psoriatic arthritis foot-specific tools. However, the LFIS-
Kate Carter, Caterina Tannous, Steven Walmsley, Keith Rome, Deborah E. Turner   +4 more
doaj   +1 more source

Translational perspectives on psoriatic arthritis. [PDF]

, 2009
The term psoriatic disease encompasses the array of disorders (arthritis, inflammatory bowel disease, uveitis, obesity, metabolic syndrome, type II diabetes, and cardiovascular disease) that are associated with psoriasis.
Proulx, Steven T, Ritchlin, Christopher T, Schwarz, Edward S, S. PROULX, RITCHLIN, CHRISTOPHER T., E. S. SCHWARZ, SCHWARZ, EDWARD S., C. T. RITCHLIN, PROULX, STEVEN   +8 more
core   +1 more source

Exome Sequencing Uncovers Phenotypic and Genotypic Heterogeneity in 196 Indian Families Evaluated for Autoinflammatory Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autoinflammatory disorders (AIDs) are a clinically heterogeneous group of inborn errors of immunity primarily caused by dysregulation in the innate immune system. Clinical diagnosis is often challenging due to clinical heterogeneity and the overlapping phenotypes with other inborn errors of immunity and monogenic conditions that mimic AIDs ...
Vaishnavi Ashok Badiger, Periyasamy Radhakrishnan, Suma Balan, Anand P. Rao, Prajna Udupa, Karthik Vijay Nair, Bhagesh Hunakunti, Adarsh Pooradan Prasannakumar, Sanket Limaye, Huzail Gani Shaikh, Rohit Naik, Mahesh Janarthanan, Sudharshan Sridharan, Vishal Sondhi, Sheela Nampoothiri, Hitesh Shah, Sabrinath Mahadevan, Mahabaleshwar Mamadapur, Devang Pandya, Katta Mohan Girisha, Abhay Shivpuri, Amita Moirangthem, Jyothi Raghuram, Gandham Sri Lakshmi Bhavani, Sachin Jeevanagi, Girish Subramaniam, Amita Aggarwal, Anju Shukla, Dhanya Lakshmi Narayanan   +28 more
wiley   +1 more source

Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 treatment recommendations for psoriatic arthritis

, 2016
Objective: To update the 2009 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for the spectrum of manifestations affecting patients with psoriatic arthritis (PsA). Methods: GRAPPA rheumatologists,
Acosta-Felquer, Maria Laura, Bochncke, Wolf-Henning, Gladman, Dafna D, Soriano, Enrique R, Espinoza, Luis R, Mease, Philip J, Kavanaugh, Arthur, FitzGerald, Oliver, Bautista-Molano, Wilson, Cauli, Alberto, Nash, Peter, Coates, Laura C, Armstrong, April W, Campbc, Willemina, et al.   +14 more
core   +1 more source

Prevalence and association of renal disorders in Saudi adult patients with psoriasis and psoriatic arthritis: a tertiary-center retrospective cross-sectional study

Dermatology Reports
Psoriasis, a chronic inflammatory skin disease, is connected to psoriatic arthritis, a chronic inflammatory arthritis. Recent studies have also linked psoriasis and psoriatic arthritis to various renal disorders.
Mishari Alrubaiaan, Abdullah Alhobabi, Raghad Alharthi, Saad Alsulaiman, Abdullah Altasan, Ibrahim Momen, Mohammad Almohideb   +6 more
doaj   +1 more source

IS PSORIATIC ARTHRITIS REALLY PSORIATIC? [PDF]

, 2014
The paper discusses the apparent rhetorical question whether psoriatic arthritis is psoriatic. Based on the data available in the literature and logical considerations, it has been suggested that accepted view may be contrary to ...
Sh. F. Erdes
core   +1 more source

Adalimumab in Psoriatic Arthritis

The Journal of Rheumatology Supplement, 2012
Open prospective studies and randomized controlled trials (RCT) have shown the short-term efficacy of adalimumab (ADA) in psoriatic arthritis (PsA) and psoriasis. ADA effectively treated all varied musculoskeletal manifestations characteristic of PsA, including peripheral arthritis, spinal disease, enthesitis, and dactylitis.
SALVARANI, CARLO, Pipitone, Nicolò, Catanoso, Mariagrazia, Chiarolanza, Ilaria, Boiardi, Luigi, Caruso, Andrea, Pazzola, Giulia, Macchioni, Pierluigi, Di Lernia, Vito, Albertini, Giuseppe   +9 more
openaire   +4 more sources

Autoantibodies to Joint‐Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

Arthritis &Rheumatology, EarlyView.
Objective To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA) and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serologic markers. Methods We analyzed serum and plasma from three cohorts: presymptomatic individuals who later developed RA ...
Outi Sareila, Linda Johansson, Anders Lundquist, Monica Leu Agelii, Lei Cheng, Yibo He, Erik Lönnblom, Maria Andersson, Jan Kihlberg, Anders Esberg, Inger Gjertsson, Rikard Holmdahl, Solbritt Rantapää‐Dahlqvist   +12 more
wiley   +1 more source