Peptide strings clues to the genesis and treatment of rheumatoid arthritis: rebuilding self-protective immunity amid fungal ruins [PDF]
A recent application of the peptide strings concept has yielded novel perceptions on cell growth regulation, for instance that of oncoprotein metastasis. Here, this interdisciplinary approach at the boundary between physics and biology has been applied to gain a more profound insight into rheumatoid arthritis.
arxiv
Lower Limb Rehabilitation in Juvenile Idiopathic Arthritis using Serious Games [PDF]
Patients undergoing physical rehabilitation therapy must perform series of exercises regularly over a long period of time to improve, or at least not to worsen, their condition. Rehabilitation can easily become boring because of the tedious repetition of simple exercises, which can also cause mild pain and discomfort.
arxiv
Rheumatoid meningitis sine arthritis. [PDF]
Rheumatoid meningitis is a rare and very serious extra-articular manifestation of rheumatoid arthritis. We present a case of a 7()year-old female with no history of arthritis who developed stroke-like symptoms, seizures, psychosis and compulsive behavior.
Berk, Matthew+3 more
core +1 more source
Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin [PDF]
Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis ( RA) by assessing a ...
A Bucht+65 more
core +2 more sources
Juvenile Idiopathic Arthritis, Earnings, and Work Loss: A Nationwide Matched Cohort Study
Objective This study compares trajectories of earnings and work loss in individuals with juvenile idiopathic arthritis (JIA) versus matched comparators from the general population. Methods Patients with JIA (n = 4,737) were identified in the Swedish National Patient Register (2001–2017) and individually matched to up to five general population ...
Heather Miller+4 more
wiley +1 more source
Background Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain in this population.
Ian C. Scott+7 more
doaj +1 more source
Hybrid clustering-classification neural network in the medical diagnostics of reactive arthritis [PDF]
The hybrid clustering-classification neural network is proposed. This network allows increasing a quality of information processing under the condition of overlapping classes due to the rational choice of a learning rate parameter and introducing a special procedure of fuzzy reasoning in the clustering process, which occurs both with an external ...
arxiv
Concept Bottleneck Models [PDF]
We seek to learn models that we can interact with using high-level concepts: if the model did not think there was a bone spur in the x-ray, would it still predict severe arthritis? State-of-the-art models today do not typically support the manipulation of concepts like "the existence of bone spurs", as they are trained end-to-end to go directly from ...
arxiv
The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites [PDF]
Among many survival strategies, parasitic worms secrete molecules to modulate host immune responses. One such product, ES-62, is protective in the collagen-induced arthritis (CIA) model of rheumatoid arthritis.
Al-Riyami+47 more
core +1 more source
Diverse Treatment Goals in Psoriatic Arthritis: Insights from participants in the PARC cohort
Objective The aim was to examine patient‐reported treatment goals among individuals with psoriatic arthritis (PsA). Methods Participants in the Psoriatic Arthritis Research Consortium (PARC) completed standardized assessments including patient‐reported outcome (PROs) instruments between 2017‐2020.
Astia Allenzara+8 more
wiley +1 more source