Results 251 to 260 of about 1,291,893 (344)

Correction. [PDF]

Can Fam Physician
europepmc   +1 more source

The Burden and Temporal Trends of Rheumatoid Arthritis in High-Income Countries and Territories, 1990-2023: A Systematic Analysis for the Global Burden of Disease Study 2023. [PDF]

Open Access Rheumatol
Mak TC, Tang CC, Choi JMC, Law KKP, Wong AYK, Lau KKL.   +5 more
europepmc   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Hidden in Plain Sight: Gonorrhea-Associated Flexor Tenosynovitis-A Case Report. [PDF]

Case Rep Infect Dis
Chavez J, Aguilar J, Ahmed M, Chaudhuri S.   +3 more
europepmc   +1 more source

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

Updates on the Evaluation of Lupus Arthritis. [PDF]

Rheumatol Ther
Tang W, Nordmann-Gomes A, Khalili L, Rosas G, Montgomery E, Zhang L, Suh S, Clancy R, Askanase AD.   +8 more
europepmc   +1 more source

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Minimally invasive, ultrasound-guided synovial tissue biopsies are well-tolerated, safe and feasible in children and young people with inflammatory arthritis. [PDF]

RMD Open
Clay E, Bolton C, Hackland A, Smith CG, Kupiec K, Kelly J, Chippington S, Sheikh Z, Foley C, Reis Nisa P, Lomholt S, Alexiou V, Turtsevich I, Pils C, Sultan S, Khan N, Thyagarajan M, Neag G, Mahony CB, Adams HR, Cotter C, Sadler M, Nguyen H, Barklam EB, Jones LJ, Chin PS, Kemble S, Marsh LJ, Davis P, Davda S, Compeyrot-Lacassagne S, Patel F, Rosser EC, Hanlon MM, Coles W, Dicarlo E, Gravallese E, Filer A, Al-Abadi E, Wedderburn LR, Croft AP.   +40 more
europepmc   +1 more source

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

Advanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao   +12 more
wiley   +1 more source