Results 301 to 310 of about 1,802,299 (400)

Cavitary pulmonary nodules in rheumatoid arthritis; case reports and review of the literature

open access: diamond, 2017
Nilüfer Alpay Kanıtez   +5 more
openalex   +2 more sources

Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension

open access: yesAdvanced Science, EarlyView.
Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu   +17 more
wiley   +1 more source

Dynamic tracking of functional gene modules in treated juvenile idiopathic arthritis

open access: gold, 2015
Nan Du   +6 more
openalex   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang   +25 more
wiley   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

open access: yesAdvanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang   +15 more
wiley   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

open access: yesAdvanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang   +6 more
wiley   +1 more source

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