Results 301 to 310 of about 1,358,299 (361)

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai, Yongde Jin, Jingmei Chai, Jianing Yang, Jiangang Wang, Mu Chen, Liangchang Li, Chongyang Wang, Guanghai Yan   +8 more
wiley   +1 more source

<i>Adu</i>CPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis. [PDF]

Front Pharmacol
Liu S, Situ Y, Deng L, Liang M, He H, Shao Z, Peng L.   +6 more
europepmc   +1 more source

A hepatoprotective experiment on taro vegetable (Colocasia esculenta (L.) Schott) flower employing animal models by mitigating oxidative stress

Animal Models and Experimental Medicine, EarlyView.
The antioxidant efficacy of Colocasia esculenta flower’s methanolic extract was assessed using 2,2′‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulfonic) (ABTS) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging assay. The hepatoprotective effect was investigated by assessing liver injury indicators (amino transferase [ALT], aspartate amino transferase [AST],
Mahathir Mohammad, Fahmida Tasnim Richi, Rabiul Hossain, Md. Arafat, Pair Ahmed Jiko, Nazim Uddin Emon, Sayed Al Hossain Rabbi, Tirtha Khastagir, Md. Hemayet Hossain, Safaet Alam   +9 more
wiley   +1 more source

Extra intestinal manifestations may increase the risk of synchronous and metachronous development of other extraintestinal manifestations in patients with Crohn's disease. [PDF]

Sci Rep
Ozkahraman A, Kayar Y, Dertli R, Konur S, Kılıc G, Baran B, Ormeci AC, Akyuz F, Demir K, Besisik F, Kaymakoglu S.   +10 more
europepmc   +1 more source

Time‐ and dose‐related pathological changes in knee osteoarthritis rat model induced by monosodium iodoacetate

Animal Models and Experimental Medicine, EarlyView.
Time‐ and dose‐related pathological changes of knee osteoarthritis rat model induced by monosodium iodoacetate. Abstract Knee osteoarthritis (KOA) is a chronic degenerative disease. Monosodium iodoacetate (MIA) induction is the most commonly used therapeutic effect evaluation and mechanism of action research model; we observed a lack of standardization
Wei Pu, Qi Liu, Shuyan Xue, Siyuan Li, Nan Nan, Yang Liu, Huiqin Hao   +6 more
wiley   +1 more source

A successful combination of upadacitinib and guselkumab in refractory psoriasis and psoriatic arthritis: A case report. [PDF]

SAGE Open Med Case Rep
Antolini S, Scagliosi G, Veliaj O, Carletto A, Fracassi E, Gisondi P.   +5 more
europepmc   +1 more source

Long noncoding RNA GCH1 mediates mitophagy via the PTEN‐induced kinase 1/Parkin pathway to drive chondrocyte dysfunction and cartilage degeneration in osteoarthritis

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract illustrates the role of lncRNA‐GCH1 in regulating mitophagy and its downstream effects on chondrocyte dysfunction and cartilage degradation in osteoarthritis (OA). Elevated lncRNA‐GCH1 stabilizes PINK1 protein, enhancing mitophagy and mitochondrial turnover.
Gang Zeng, Yujun Sun, Taihe Liu, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Weidong Song, Yue Ding   +8 more
wiley   +1 more source

Misdiagnosis of psoriatic arthritis in a patient with paronychia confirmed by dermatological examination: A case report. [PDF]

World J Clin Cases
Nigro A.
europepmc   +1 more source

Systematic review of the subcutaneous air pouch model using monosodium urate and calcium pyrophosphate and recommendations for studying crystal‐related arthropathies

Animal Models and Experimental Medicine, EarlyView.
Simplified schematic for generation of the subcutaneous air pouch model in the rodent. On day 0 and 4, air is injected into the subcutaneous space on the dorsal surface of the rodent to generate a cavity analogous to a synovial joint. On day 6, monosodium urate (MSU) or calcium pyrophosphate (CPP) crystals are injected into the pouch to stimulate ...
Wenu Hewage, Josif Vidimce, Ryan G. Shiels, Michael Morgan, Andrew C. Bulmer   +4 more
wiley   +1 more source

Association between rheumatoid arthritis and kidney stones: A cross-sectional study of NHANES 2007-2020. [PDF]

Arthritis Res Ther
Yue G, Yan Y, Zeng X, Liu R, He T, Liu Y.   +5 more
europepmc   +1 more source