Results 71 to 80 of about 354,404 (341)

Lattice Structures for Bone Replacement: The Intersection of Bone Biomechanics, Lattice Design, and Additive Manufacturing

Advanced Materials Technologies, EarlyView.
This review outlines how understanding bone's biology, hierarchical architecture, and mechanical anisotropy informs the design of lattice structures that replicate bone morphology and mechanical behavior. Additive manufacturing enables the fabrication of orthopedic implants that incorporate such structures using a range of engineering materials ...
Stylianos Kechagias, Maxwell J. Munford, Frederik C.H. Masure, Richard J. van Arkel, Reece N Oosterbeek   +4 more
wiley   +1 more source

A new mini-navigation tool allows accurate component placement during anterior total hip arthroplasty. [PDF]

, 2018
Introduction: Computer-assisted navigation systems have been explored in total hip arthroplasty (THA) to improve component positioning. While these systems traditionally rely on anterior pelvic plane registration, variances in soft tissue thickness ...
Benson, Jessica R., Muir, Jeffrey M., Parvizi, Javad, MD   +2 more
core   +1 more source

Stemmed Versus Nonstemmed Tibia in Primary Total Knee Arthroplasty: A Similar Pattern of Aseptic Tibial Loosening in Obese Patients with Moderate Varus. 5-Year Outcomes of a Randomized Controlled Trial [PDF]

, 2022
Molham M. Mohammad, Mohammed M. Elesh, Ihab I El-Desouky   +2 more
openalex   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Scintigraphic assessment of bone status at one year following hip resurfacing : comparison of two surgical approaches using SPECT-CT scan [PDF]

, 2012
Objectives: To study the vascularity and bone metabolism of the femoral head/neck following hip resurfacing arthroplasty, and to use these results to compare the posterior and the trochanteric-flip approaches.
Amarasekera HW, Amarasekera HW, Beaulé PE, Beaulé PE, Bolland BJ, Calder SJ, Carrothers AD, Cheng D, Collier BD, Crock HV, Fordyce MJ, Forrest N, Freeman MA, Ganz R, Gholamrezanejhad A, Horger M, Jiang Y, Khan A, Koch GG, Linke R, Mariani G, McMahon SJ, Patterson AH, Prime MS, Ryu JS, Scharf S, Shimmin AJ, Steffen RT, Steffen RT, Thickman D, van der Bruggen W, Whiteside LA   +31 more
core   +1 more source

Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China

Advanced Science, EarlyView.
The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang, Yi Liu, Ziying Sun, Jia Li, Zhihao Lu, Jiayuan Huang, Shixian Hu, Peihua Cao, Xiaolong Cao, Shangru Li, Jianzhao Ruan, Jinhui Liu, Jingyu Xie, Haitao Sun, Tianyu Chen, Shengfa Li, Zhaohua Zhu, Zhibo Wen, Rocky S. Tuan, David John Hunter, Zhong Alan Li, Dongquan Shi, Changhai Ding   +22 more
wiley   +1 more source

Increased early mortality and morbidity after total hip arthroplasty in patients with socioeconomic disadvantage: a report from the Swedish Hip Arthroplasty Register

Acta Orthopaedica, 2019
Background and purpose — Socioeconomic status is associated with the outcome of major surgery. We investigated the association of socioeconomic status with the risk of early mortality and readmissions after primary total hip arthroplasty (THA).
Rüdiger J Weiss, Johan Kärrholm, Ola Rolfson, Nils P Hailer   +3 more
doaj   +1 more source

Biomechanical Evaluation of the Accuracy in Radiographic Assessment of Femoral Component Migration Measurement after Total Hip Arthroplasty [PDF]

, 2020
Introduction: Implant subsidence is one criteria utilized to monitor for prosthesis loosening after total hip arthroplasty (THA) with initial implant subsidence assessment often done utilizing plain radiographs.
Chong, Alexander, Forness, Mikayla, Noonan, Benjamin, Podoll, Zachary   +3 more
core   +2 more sources

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Indices of systemic inflammation for predicting early infections after major joint arthroplasty

Travmatologiâ i Ortopediâ Rossii
Background. Infectious complications after arthroplasty pose a serious problem for both the patient and the health facility. Therefore, their prognosis is of great clinical importance.
Lyudmila V. Lyubimova, Evgeniya A. Mikishanina, Nikolay S. Nikolaev, Evgeniy A. Lyubimov, Elena V. Preobrazhenskaya   +4 more
doaj   +1 more source