Results 81 to 90 of about 503,391 (396)

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

open access: yesAdvanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng   +15 more
wiley   +1 more source

Increased early mortality and morbidity after total hip arthroplasty in patients with socioeconomic disadvantage: a report from the Swedish Hip Arthroplasty Register

open access: yesActa Orthopaedica, 2019
Background and purpose — Socioeconomic status is associated with the outcome of major surgery. We investigated the association of socioeconomic status with the risk of early mortality and readmissions after primary total hip arthroplasty (THA).
Rüdiger J Weiss   +3 more
doaj   +1 more source

Blood loss in primary total knee arthroplasty-body temperature is not a significant risk factor-a prospective, consecutive, observational cohort study [PDF]

open access: yes, 2015
BACKGROUND: Hypothermia related to anaesthesia and operating theatre environment is associated with increased blood loss in a number of surgical disciplines, including total hip arthroplasty.
Beller, Elaine   +5 more
core   +2 more sources

Recent updates for biomaterials used in total hip arthroplasty

open access: yesBiomaterials Research, 2018
BackgroundTotal hip arthroplasty (THA) is probably one of the most successful surgical interventions performed in medicine. Through the revolution of hip arthroplasty by principles of low friction arthroplasty was introduced by Sir John Charnley in 1960s.
C. Hu, T. Yoon
semanticscholar   +1 more source

Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention

open access: yesAdvanced Science, EarlyView.
This study shows that nasal mucosa‐derived extracellular vesicles (nmEVs) exert systemic anti‐ageing effects in mice by restoring circadian rhythm, suppressing cellular senescence, and improving cognitive function. In aged human bone marrow mesenchymal stem cells, nmEVs reverse senescence‐associated phenotypes and reactivate core clock gene expression.
Wentao Shi   +14 more
wiley   +1 more source

Influence of cementless hip stems on femoral cortical strain pattern depending on their extent of porous coating [PDF]

open access: yes, 2012
The extent of porous coating of cementless total hip stems is held responsible for radiological periprosthetic changes, the rate of thigh pain, and even its long-term success.
Bader, Rainer   +3 more
core   +1 more source

Bone-to-bone and implant-to-bone impingement : a novel graphical representation for hip replacement planning [PDF]

open access: yes, 2020
Bone-to-bone impingement (BTBI) and implant-to-bone impingement (ITBI) risk assessment is generally performed intra-operatively by surgeons, which is entirely subjective and qualitative, and therefore, lead to sub-optimal results and recurrent ...
Elliott, Mark T.   +6 more
core   +1 more source

Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China

open access: yesAdvanced Science, EarlyView.
The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang   +22 more
wiley   +1 more source

Patient-reported outcome measures in arthroplasty registries

open access: yesActa Orthopaedica, 2016
The International Society of Arthroplasty Registries (ISAR) Steering Committee established the Patient-Reported Outcome Measures (PROMs) Working Group to convene, evaluate, and advise on best practices in the selection, administration, and interpretation
O. Rolfson   +11 more
semanticscholar   +1 more source

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