Results 101 to 110 of about 80,150,569 (305)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Lexical bundles in accepted and rejected Scopus-indexed hard science research article introductions
Lexical bundles are essential components of academic discourse, contributing to linguistic fluency in written and spoken communication. Their role is particularly crucial in publishing research articles in high-impact international journals.
Kurniawan, Eri, Permatasari, Cicih
core +1 more source
Addendum: Impolite Communication Practices as a Community-Building Tool in Sports News Comments
, 2023 The Editorial Office of SibScript would like to report about the addition of information in the published article: Shulginov V. A., Alyansky K. A. Impolite Communication Practices as a Community-Building Tool in Sports News Comments.
article Editorial
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
ÖRGÜTLERDE SİBER ZORBALIK VE İLETİŞİM BECERİLERİ: AKADEMİ ÖRNEĞİ
EtkileşimBu araştırmada akademisyenlerin siber zorbalık ve iletişim dinamiklerine yönelik görüşleri derinlemesine incelenmiştir. Bu doğrultuda 14 akademisyen ile derinlemesine görüşmeler gerçekleştirilmiştir.
Seda Gökçe TURAN
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Journal Impact Factor Versus Eigenfactor and Article Influence [PDF]
This paper examines the practical usefulness of two new journal performance metrics, namely the Eigenfactor score, which is said to measure "importance", and Article Influence score, which is said to measure "prestige", using the most recent ISI data for
Michael McAleer +2 more
core +2 more sources