Results 91 to 100 of about 57,433,167 (306)

Four Flats News Article

open access: yes, 1950
Christian Faith Record Club news bulletin featuring the Four Flats (World Vision Quartet).
George Fox University Archives
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

¿Es el artículo una unidad pragmática? Acerca de la teoría de la definitud y la referencia

open access: yesStudia Romanica Posnaniensia, 2021
In this paper I intend to review some theories of the article, paying attention to the relations they establish between reference and +/–definiteness of a noun phrase (NP).
Janusz Pawlik
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

THE SPECIFICITY OF CORRELATION CATEGORY REALIZATION IN THE MODERN GERMAN LANGUAGE

open access: yesВестник Волгоградского государственного университета: Серия 2. Языкознание, 2014
The article studies the German article in functional aspect taking into account the conception of the grammatical category of correlation / non-correlation, proposed by L.R. Zinder and T.V. Stroeva. The author describes the specificity of the correlation
Goryunova Yuliya Nikolaevna
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Overview of Bjelland Vineyards Article [PDF]

open access: yes, 1976
This article relates the origin story of Bjelland Vineyards and its available wines, including an invitation from Paul and Mary Bjelland to visit the winery and enjoy a picnic on their property.
The News-Review
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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