Results 51 to 60 of about 54,983,445 (354)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Modelos ortogonais para a estimativa multivariada de VAR (Value-at-risk) para risco de mercado: um estudo de caso comparativo

Revista de Economia Mackenzie, 2011
O presente trabalho tem como objetivo explorar diferentes modelos de estimativa da distribuição conjunta de fatores para risco de mercado, com ênfase nos modelos ortogonais. Foram explorados cinco modelos: 1.
João Luiz Chela, Jean Carlos Abrahão, Luiz Fernando Ohara Kamogawa   +2 more
doaj  

Desarrollo profesional docente en TIC en contextos interculturales. La experiencia del Bachillerato en Ciencias de la Educación I y II ciclos, con énfasis en Lengua y Cultura Cabécar

Innovaciones Educativas, 2021
La experiencia del proceso de formación en el uso de las tecnologías de la información y la comunicación (TIC), implementada en el proyecto que imparte la carrera interuniversitaria de bachillerato en Ciencias de la Educación I y II Ciclos, con énfasis ...
Jenny Seas Tencio
doaj   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Douglas County Wineries Article [PDF]

, 2015
The locations of wine and vineyard establishments, their names, whether they grow grapes or make wine, and all the varieties grown in Douglas County, Oregon are labeled on a custom map which appeared in an issue of the Roseburg News ...
The News-Review
core   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

ÖRGÜTLERDE SİBER ZORBALIK VE İLETİŞİM BECERİLERİ: AKADEMİ ÖRNEĞİ

Etkileşim
Bu araştırmada akademisyenlerin siber zorbalık ve iletişim dinamiklerine yönelik görüşleri derinlemesine incelenmiştir. Bu doğrultuda 14 akademisyen ile derinlemesine görüşmeler gerçekleştirilmiştir.
Seda Gökçe TURAN
doaj   +1 more source

Retraction: Metabolism Determination By Soft Computing Methods From Breath Molecules

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2023
The article whose title is given above was retracted by the decision of the Editorial Board upon the request of the authors.
Ismail Bayraklı, Hatice Akman, Sedat Metlek   +2 more
doaj  

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source