Results 71 to 80 of about 3,253,670 (325)
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma+8 more
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto+2 more
wiley +1 more source
Identification of multidisciplinary research based upon dissimilarity analysis of journals included in reference lists of Wageningen University & Research articles [PDF]
This paper discusses the identification of journal articles that probably report on multidisciplinary research. Identification of these articles may be important for strategic purposes for the institution where the research is performed or for the evaluation of researchers or groups.
arxiv
Identification of novel small molecule inhibitors of ETS transcription factors
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla+9 more
wiley +1 more source
Earlier Web Usage Statistics as Predictors of Later Citation Impact [PDF]
The use of citation counts to assess the impact of research articles is well established. However, the citation impact of an article can only be measured several years after it has been published. As research articles are increasingly accessed through the Web, the number of times an article is downloaded can be instantly recorded and counted. One would
arxiv
Objectives To assess why articles are retracted from BioMed Central journals, whether retraction notices adhered to the Committee on Publication Ethics (COPE) guidelines, and are becoming more frequent as a proportion of published articles.
E. Moylan, Maria K Kowalczuk
semanticscholar +1 more source
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti+3 more
wiley +1 more source
A Social Network Analysis of Articles on Social Network Analysis [PDF]
A collection of articles on the statistical modelling and inference of social networks is analysed in a network fashion. The references of these articles are used to construct a citation network data set, which is almost a directed acyclic graph because only existing articles can be cited.
arxiv
Social context prevents heat hormetic effects against mutagens during fish development
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere+5 more
wiley +1 more source