Results 91 to 100 of about 867,155 (308)

Bioinspired Soft‐Skeleton Robotics With Cooperative Shape Transformation and Stiffness Adaptation

Advanced Robotics Research, EarlyView.
A bioinspired soft‐skeleton robot that integrates variable‐stiffness chain skeletons into a soft textile skin is developed. The chain skeletons are highly flexible initially but can stiffen upon pneumatic actuation, enabling large deformation and enhanced load‐bearing capacity.
Mengyuan Niu, Xiaorui Hu, Chenmin Yuan, Haoyun Li, Xuzhong Su, Fengxin Sun   +5 more
wiley   +1 more source

Longterm results of open surgical repair of rotator cuff tears

Acta Orthopaedica et Traumatologica Turcica, 2020
Objectives: We evaluated the long-term results of rotator cuff tears treated by open surgical repair.\nMethods: Ninety shoulders of 88 patients (36 females, 52 males; mean age 57 years; range 36 to 75 years) with rotator cuff tears were treated by open ...
Murat Bezer, Baris Kocaoglu, Bulent Erol, Nuri Aydin, Osman Guven   +4 more
doaj  

Preliminary characterisation of the surface of cartilage following exposure to saturated and unsaturated synthetic lips [PDF]

, 2011
Articular cartilage is covered by a microscopic structure known as surface amorphous layer. This surface structure is often the first victim of attack during cartilage degeneration, thereby resulting in a gross impairment in cartilage function such as ...
Gudimetla, Prasad, Oloyede, Adekunle, Pawlak, Zenon, Yusuf, Kenny   +3 more
core   +2 more sources

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

The thickness of the calcified layer of articular cartilage [PDF]

, 1987
The thickness of both the articular cartilage and its calcified zone were measured at 25 carefully selected points in 8 human femoral heads, and the ratio of one to the other was found to be remarkably constant for each bone.
Müller-Gerbl, Magdalena, Putz, Reinhard, Schulte, Erik   +2 more
core  

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

An Observational Study on the Prediction of Range of Motion in Soldiers Diagnosed with Patellar Tendinopathy Using Ultrasound Shear Wave Elastography

Bioengineering
Introduction: This study hypothesized that changes in the elasticity of the quadriceps and patellar tendons before and after the diagnosis of patellar tendinopathy would correlate with the range of motion (ROM) following conservative treatment.
Min-Woo Kim, Dong-Ha Lee, Young-Chae Seo
doaj   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Fibular transfer in a nineweekold infant for complete congenital absence of the tibia

Acta Orthopaedica et Traumatologica Turcica, 2021
The treatment of complete congenital absence of the tibia is controversial. The goal of the treatment is to construct a satisfactorily functioning knee joint, for which fibular transfer was described as an appropriate method.
Lokman Karakurt, Erhan Yilmaz, Mustafa Avci, Erhan Serin   +3 more
doaj